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acetylcholinesterase inhibitor |
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In general, although both AChE isoforms are inducible by cholinesterase inhibitors or by neural injury, the expression of AChE-R appears to be related to neuroprotection and repair, whereas AChE-S, either by itself or when up-regulated in conjunction with AChE-R, is more highly associated with injury and increasing neurotoxicity (Cohen et al. Scientists do not yet fully understand how cholinesterase inhibitors work to treat AD, but current research indicates that they prevent the breakdown of acetylcholine, a brain chemical believed to be important for memory and thinking. Researchers are investigating whether patients can get more benefit from using memantine along with cholinesterase inhibitors, Reisberg says. |
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