Chloroquine-Resistant Malaria

P falciparum which is resistant to chloroquine—a pharmacologic ‘staple’ used to treat and as prophylaxis for visitors to malaria endemic regions of Africa
Mechanism of resistance Resistant strains of P falciparum do not concentrate chloroquine; resistance is reversed by verapamil, a calcium channel blocker
References in periodicals archive ?
Drugs for chloroquine-resistant malaria are quinine, sulfadoxine-pyrimethamine combination, mefloquine, artesunate and its derivatives, halfantrine and certain antibiotics.
Chloroquine-resistant malaria in travelers returning from Haiti after 2010 earthquake.
There is no role for chloroquine because chloroquine-resistant malaria is present in this country.
Chloroquine-resistant malaria is found in parts of Namibia although prevalence can vary at different times of the year.
Menhadenfish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice.
Update on hypothesis linking chloroquine-resistant malaria to disease-causing HIV.
For example, chloroquine-resistant malaria is widespread in sub-Saharan Africa, including Nigeria, and resistance to sulfadoxine-pyrimethamine also occurs in this region.
Unfortunately, chloroquine-resistant malaria is common throughout Africa, so bowhunters heading there must choose from three alternatives.
DNDi's initial drug development efforts are aimed at chloroquine-resistant malaria, human African trypanosomiasis (sleeping sickness), visceral leishmaniasis (also called kala-azar), and Chagas disease.
Because of the danger of traveling to areas where chloroquine-resistant malaria is endemic, pregnant women should think twice before traveling to such areas as east Africa and Thailand.
This report summarizes the investigation of the two cases and underscores the need for clinicians and travelers to know the recommended options for malaria chemoprophylaxis when traveling to locations with chloroquine-resistant malaria.
The MSS-HTA was compared with a standard allele-restricted PCR (ARPCR) in clinical samples from Malawi, a country where standard PCR analyses and a recent clinical trial have suggested that chloroquine-resistant malaria has disappeared (6-9).