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Chloroquine-Resistant Malaria

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Chloroquine-Resistant Malaria
P falciparum which is resistant to chloroquine—a pharmacologic ‘staple’ used to treat and as prophylaxis for visitors to malaria endemic regions of Africa
Mechanism of resistance Resistant strains of P falciparum do not concentrate chloroquine; resistance is reversed by verapamil, a calcium channel blocker


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He also directs a project in Malawi, Africa where his team discovered that chloroquine-resistant malaria disappeared after several years of stopping use of the drug.
Unfortunately, chloroquine-resistant malaria is common throughout Africa, so bowhunters heading there must choose from three alternatives.
DNDi's initial drug development efforts are aimed at chloroquine-resistant malaria, human African trypanosomiasis (sleeping sickness), visceral leishmaniasis (also called kala-azar), and Chagas disease.
 
 
 
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