chloroquine (redirected from Chloroquine hydrochloride)

chloroquine /chlo·ro·quine/ (klor´o-kwin) an antiamebic and anti-inflammatory used in the treatment of malaria, giardiasis, extraintestinal amebiasis, lupus erythematosus, and rheumatoid arthritis; used also as the hydrochloride and phosphate salts.

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Chloroquine

An antimalarial drug that was first used in the 1940s, until the first evidence of quinine resistance appeared in the 1960s. It is now ineffective against falciparum malaria almost everywhere. However, because it is inexpensive, it is still the antimalarial drug most widely used in Africa. Native individuals with partial immunity may have better results with chloroquine than a traveler with no previous exposure.

Mentioned in: Malaria

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chloroquine

[klôr′əkwīn′]

an antimalarial.

indications It is prescribed in the treatment of malaria, extraintestinal amebiasis, rheumatoid arthritis, discoid lupus erythematosus, scleroderma, pemphigus, and photoallergic reactions.

contraindications Retinal or visual field changes, porphyria, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse reactions are GI disturbances, headache, visual disturbances resulting from retinal damage, and pruritus. It can turn the skin blue/black and/or the urine brown/black, bleach the hair, and cause photosensitivity.

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chloroquine

an antiprotozoal agent, used in the treatment of avian malaria, anaplasmosis and theileriosis in cattle and amebiasis in non-human primates.

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chloroquine poisoning

the drug has an affinity for melanin and ocular tissues with melanin; causes a drug-induced retinopathy.