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Chloroquine |
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chloroquine /chlo·ro·quine/ (klor´o-kwin) an antiamebic and anti-inflammatory used in the treatment of malaria, giardiasis, extraintestinal amebiasis, lupus erythematosus, and rheumatoid arthritis; used also as the hydrochloride and phosphate salts. Chloroquine An antimalarial drug that was first used in the 1940s, until the first evidence of quinine resistance appeared in the 1960s. It is now ineffective against falciparum malaria almost everywhere. However, because it is inexpensive, it is still the antimalarial drug most widely used in Africa. Native individuals with partial immunity may have better results with chloroquine than a traveler with no previous exposure. Mentioned in: Malaria chloroquine an antiprotozoal agent, used in the treatment of avian malaria, anaplasmosis and theileriosis in cattle and amebiasis in non-human primates. chloroquine poisoning the drug has an affinity for melanin and ocular tissues with melanin; causes a drug-induced retinopathy. |
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? Mentioned in | ? References in periodicals archive | |
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Both patients had a chief report of fever with no source, but malaria was suspected by the attending physician, and 1 patient was treated with chloroquine. Beginning in the 1950s, chloroquine halted malaria's march in Africa and Asia. Quinolones are synthetic derivatives of nalidixic acid, which was discovered during the purification of the anti-malaria agent chloroquine. |
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