Chlamydia pneumoniae

Chla·myd·i·a pneu·mo·ni·ae

a species first isolated in 1986 and currently recognized as a common cause of pneumonia, bronchitis, rhinosinusitis, and pharyngitis in both adults and children.
Synonym(s): TWAR

Chlamydia pneumoniae is responsible for about 25% of cases of acute bronchitis and 10% of community-acquired pneumonia. It may also play a role in the genesis of cardiovascular disease and late-onset Alzheimer dementia. Like C. trachomatis and C. psittaci, this organism is an occasional cause of myocarditis and endocarditis. Elevated levels of antibody to C. pneumoniae are found in patients with acute myocardial infarction (MI) and in those showing severe atheroma formation at autopsy significantly more often than in control groups. The organism has been detected by immunocytochemistry, polymerase chain reaction, and electron microscopy in macrophages and smooth muscle cells of atheromatous plaques of the aorta, coronary arteries, and carotid arteries (surgical and autopsy specimens), but not in normal arteries. The incidence of acute infection in MI patients, as detected by throat culture, is higher than in the general public. A retrospective review of medical records of patients with acute MI showed that they were less likely than matched controls to have been treated during the preceding 3 years with tetracycline or quinolone antibiotics, which are active against C. pneumoniae. To date, however, prospective studies have not shown an association between the presence of IgG antibody to C. pneumoniae and an increased risk of atherothrombotic disease. The current body of evidence favors infection with C. pneumoniae as one of several factors capable of initiating changes that culminate in atherosclerosis. Limited studies suggest that antibiotic treatment may reduce the risk of recurrent coronary events, but have not shown benefits in stable coronary artery disease. Antibody to C. pneumoniae is also found in patients with severe hypertension at about twice the incidence rate for the general public, and has been linked statistically to accelerated loss of lung function in patients with asthma. In addition, the organism has been detected in microglia and astroglia of the hippocampus and temporal cortex in patients with late-onset Alzheimer disease with much greater frequency than in normal brains.

Chlamydia pneumoniae

C psittaci TWAR A pathogen that causes pneumonia, asymptomatic RTIs, pharyngitis, otitis media

Chla·myd·o·phil·a pneu·mo·ni·ae

(klă-midō-filă nū-mōnē-ē)
A species that causes pneumonia and upper and lower respiratorydisease. Also called Chlamydia pneumoniae (q.v.), TWAR.

Chla·myd·i·a pneu·mo·ni·ae

(klă-mi'dē-a nū-mō'nē-ē)
A species recognized as a common cause of pneumonia, bronchitis, rhinosinusitis, and pharyngitis.
Synonym(s): TWAR.
References in periodicals archive ?
Detection of specific Chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a Chinese population.
Development of a multiplex real-time quantitative PCR assay to detect Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae in respiratory tract secretions.
1] Although a number of different viral, bacterial, fungal and protozoan organisms can cause atypical pneumonia, the three most common are Chlamydia pneumoniae, Legionella pneumophila, and Mycoplasma pneumoniae.
One of the most reported findings is a detection of fragments, DNA and antibodies against Chlamydia pneumoniae, Ch.
The company has also created unique Point-of Care tests for Mycoplasma pneumoniae and Chlamydia pneumoniae which allow the getting the results in 10 minutes from one fingertip blood drop.
One of his earliest published studies was published in JAMA in 1991, when he made the observation that asthma was seen in patients experiencing bronchitis or pneumonia caused by Chlamydia pneumoniae.
Due to absence of any positive history or sign for other fungal agents, yersiniosis, or Chlamydia pneumoniae infection, we did not perform further diagnostic tests.
Chlamydia spp were not detected in wild birds; however, 4 species (Chlamydia psittaci, Chlamydia pecorum, Chlamydia pneumoniae, and Chlamydia gallinacea) were identified among captive birds (Passeriformes, n = 20; Psittaciformes, n = 15; Rheiformes, n = 8; Falconiformes, n = 2; Piciformes, n = 2; Anseriformes, n = 1; Galliformes, n = 1; Strigiformes, n = 1).
There was a low yield in microbiological specimens with no pathogen identified in two-thirds of the patients which could be attributed to the non-availability of serological tests for atypical pathogens such as Mycoplasma and Chlamydia pneumoniae.
Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections.
Researchers found an index of antibody levels caused by exposure to Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex viruses 1 and 2 was associated with worse cognitive performance, including memory, speed of mental processing, abstract thinking, planning and reasoning ability.