Chinese herb nephropathy

Chinese herb nephropathy

A progressive form of renal fibrosis that develops in some patients taking weight-reducing pills containing Chinese herbs, including Aristolochia fangchi, which is nephrotoxic and carcinogenic. Surgical specimens from patients with Chinese herb nephropathy contain DNA adducts formed by aristolochic acid; the cumulative dose of aristolochia was a significant risk factor for urothelial carcinoma.
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Ingestion of aristolochic acid has been linked to a newly defined entity, Chinese herb nephropathy (CHN).
The results of the analysis clearly indicated the presence of aristolochic acid in 2 of the 6 Chinese herbs prescribed, compatible with the diagnosis of Chinese herb nephropathy (CHN).
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