chemotherapeutic agent


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Related to chemotherapeutic agent: chemotherapy

chemotherapeutic agent

[-ther′əpyo̅o̅′tik]
any chemical used to treat cancer. It is usually used to refer to antineoplastic drugs.

chemotherapeutic agent

An agent used to treat cancer administered in regimens of one or more cycles, combining two or more agents over a period of days to weeks. Such agents are toxic to cells with high proliferative rates—e.g., to the cancer itself, but also to the GI tract (causing nausea and vomiting), bone marrow (causing various cytopenias) and hair (resulting in baldness).

Examples
Busulphan, cisplatin, cyclophosphamide, MTX, daunorubicin, doxorubicin, melphalan, vincristine, vinblastine, chlorambucil.

chemotherapeutic agent

An agent used to treat CA, administered in 'regimens'-one or more 'cycles' that combine 3 or more agents over wks; CAs are toxic to any cell with a high rate of proliferation–the CA itself, the GI tract–causing N&V, BM–cytopenias, and hair—alopecia Examples Busulphan, cisplatin, cyclophosphamide, MTX, daunorubicin, doxorubicin, melphalan, vincristine, vinblastine, chlorambucil. See Immunosuppressive agents.

che·mo·ther·a·peu·tic a·gent

(kēmō-thār-ă-pyūtik ājĕnt)
Chemical that is used for therapeutic reasons.
References in periodicals archive ?
Three current local chemotherapeutic agents are reviewed in this paper: doxycycline gel, chlorhexidine chip and minocycline microspheres.
One of the significant limitations of chemotherapeutic agents is their poor selectivity, and doses which are required to kill tumor cells cause unacceptable toxicities to normal tissues.
AmpliMed Corporation was founded in 1989 with the support of the University of Arizona Technology Development Corporation and is focused on the clinical development of chemotherapeutic agents for cancer.
The APF530 Phase 3 pivotal trial protocol includes a total of approximately 1,350 patients, about half of which will receive moderately emetogenic chemotherapeutic agents with the other half receiving highly emetogenic chemotherapeutic agents.
Conventional doxorubicin is one of the world's most widely used chemotherapeutic agents.
This is an important distinction between ONCONASE over other standard chemotherapeutic agents (DNA damaging agents).
Scientists at CTI demonstrated that chemotherapeutic agents such as 5-fluorouracil (5-FU) or paclitaxel (Taxol) stimulate a lipid intracellular messenger, phosphatidic acid (PA), which results in the production of several hematopoietic inhibitors, such as transforming growth factor beta (TGF-B) and tumor necrosis factor alpha (TNF-A).
In functioning as a DNA repair enzyme, pol beta is believed to play a key role in the development of resistance to platinum-containing chemotherapeutic agents, which produce their anti-proliferative effects by damaging the DNA of cancer cells.
Recent research has indicated that one mode of action of chemotherapeutic agents may be to induce apoptosis, or cell suicide, by causing DNA damage in the cancer cells.
Nasdaq: IMGN) today announced the start of a Phase I/II clinical trial in lymphoma patients designed to use its lead product, Oncolysin B, to "sensitize" tumor cells resistant to conventional chemotherapeutic agents to additional treatment with those agents.
The objectives of the trial are to assess the safety of several doses of CA4P in combination with the two chemotherapeutic agents, gather data on anti-tumor activity and establish a recommended Phase II/III dose.