References in periodicals archive ?
By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines.
Multitargeted Therapies: Promiscuous Drugs and Combination Therapies' discusses the emerging discipline of network pharmacology, which combines network biology with chemogenomics.
Their topics include organizing bioactive compound discovery in target gene families, cofactor chemogenomics, chemogenomics with protein secondary-structure mimetics, database systems for knowledge-based discovery, off-target networks derived from ligand set similarity, the chemogenomic analysis of safety profiling data, network and pathway analysis of compound-protein interactions, the flexible pocketome engine for structural chemogenomics, analyzing protein family landscapes with structure-based chemogenomics, and hypothesis-driven screening.
serving as Vice President of Biology and Chemogenomics and Vice President of New Technology and Translational Medicine from 1998 to 2007.
A discussion of the patent and two new applications --known as transitional structural chemogenomics and transitional structural chemoproteomics -- was published in the May 2006 issue of Medical Hypotheses (67:1099-1114).
We are very pleased to be working with Elsevier MDL, the market leader in medicinal chemistry knowledge databases, Integration with the Elsevier MDL chemistry space opens up new applications for our products in medicinal chemistry, including high-throughput and high-content screening, hit selection and validation, lead development programs and chemogenomics.
The company's discovery engines integrate cell cycle biology expertise with a large library of gene-based targets, state-of-the-art RNAi functional genomics, chemogenomics and clinical biomarker technologies to rapidly deliver new drugs.
Iconix Pharmaceutical linked its DrugMatrix chemogenomics prediction system to MDL Information Systems' ISIS Enterprise Edition .
The new cluster provides increased power and scalability as we expand our chemogenomics platform to support parallel drug design in multiple gene families.
OHSU scientists will use MetaCore for pathway analysis; MetaDrug for chemogenomics, MapEditor for pathway editing and communication and MetaLink for adding their own interactions to MetaCore's manually curated pathways.
Iconix will receive compensation from Lilly in exchange for access to Iconix's DrugMatrix(R) chemogenomics system and its Drug Signatures(R) library.
In addition, the company offers six other databases, ranging from ZooSeq which features gene sequence information for laboratory animals to its new DrugMatrix chemogenomics database.
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