Charcot-Leyden crystal


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Related to Charcot-Leyden crystal: Charcot triad, asthma crystals

Charcot-Leyden crystal

[shärkō′lī′dən]
Etymology: Jean M. Charcot; Ernst V. von Leyden, German physician, 1832-1910
any of the proteinaceous crystalline structures shaped like narrow, double pyramids found in the sputum of persons suffering from asthma and found in the feces of dysentery patients. Charcot-Leyden crystals occur in association with the fragmentation of eosinophils. Also called asthma crystal, leukocytic crystal.

Charcot-Leyden crystal

(shăr-kō′lī′dĕn)
[Charcot; Ernest V. von Leyden, Ger. physician, 1832–1910]
A type of colorless, hexagonal, double-pointed, often needle-like crystal found in the sputum in asthma and bronchial bronchitis or in the feces in ulceration of the intestine, esp. amebiasis.
References in periodicals archive ?
Charcot-Leyden crystals (CLCs) are accepted as a morphologic hallmark of eosinophil-related disease in which there is active eosinophilic inflammation or proliferation.
Formation of Charcot-Leyden crystals in human eosinophils and basophils and study of the composition of isolated crystals.
These cases demonstrated the ultrastructural features of Charcot-Leyden crystals.
The persistence of symptoms, required taking a second sample where isolating the fungus and visualizing fungal structures in the direct examination and the histopathology permitted establishing the diagnosis ofnon-invasive fungal sinusitis since allergic mucin with Charcot-Leyden crystals were not observed, nor significant eosinophilia, or tissue or vascular invasion (4).
Charcot-Leyden crystals consist of a 13 000-molecular weight acidic protein whose amino acid composition distinguished it from the 9300-molecular weight major basic protein, the principal constituent of eosinophil large granules; this protein is identical to lysophospholipase (3) and is stained by basic fuchsin in the Ziehl-Neelsen method.
The minor criteria include asthma, unilateral predominance, radiographic bone erosion, fungal culture, Charcot-Leyden crystals, and serum eosinophilia.
Presence of Charcot-Leyden crystals may offer a clue in acute phase biopsies.

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