challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
Interestingly, a Black Swallower is, in many ways, akin to a challenger brand.
AC: To be a challenger on Iron Chef America is a holy grail for some chefs.
Early returns for the College of the Canyons board showed incumbent Ernie Tichenor leading the race for Office 1 over challenger Jonathan Kraut.
Kellen Hobie added two doubles and two RBI for the Challengers.
Hope for this plan, too, depends on the consequences of the Challenger affair, but the time required to procure, install and test the necessary modifications to Discovery require NASA to get an early start even to keep the option open.
Our 1970 Challenger program is designed to fulfill those wishes with a very, very small run of an even more exclusive MOPAR.
Other challengers were Paul Cramer, Steven DeMarzio, and Joan Sodergren.
An analysis was conducted of each incumbent and challenger detailing their VoIP offering in terms of market background, pricing, product features and branding, both corporate and residential.
The mayor also has said he has not decided when he will appear in a debate with his challengers.
Incumbent director David Rizzo will face challenger Maurice Kunkel, who is a retired meteorologist and member of the Wilsona School District board.