Chagas disease

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South A·mer·i·can try·pan·o·so·mi·a·sis

trypanosomiasis caused by Trypanosoma (or Schizotrypanum) cruzi and transmitted by certain species of reduviid (triatomine) bugs. In its acute form, it is seen most frequently in young children, with swelling of the skin at the site of entry, most often the face, and regional lymph node enlargement; in its chronic form it can assume several aspects, commonly cardiomyopathy, but megacolon and megaesophagus also occur; natural reservoirs include dogs, armadillos, rodents, and other domestic, domiciliated, and wild mammals.

South A·mer·i·can try·pan·o·so·mi·a·sis

(sowth ă-mer'i-kăn trī-pan'ō-sŏ-mī'ă-sis)
Disease caused by Trypanosoma (or Schizotrypanum) cruzi and transmitted by some species of reduviid (triatomine) bugs. In its acute form, it is seen most frequently in young children, with swelling of the skin at the site of entry, most often the face, and regional lymph node enlargement; in its chronic form it can assume several aspects, commonly cardiomyopathy, but megacolon and megaesophagus also occur; natural reservoirs include domestic, domiciliated, and wild mammals.
Synonym(s): Chagas disease, Chagas-Cruz disease, Cruz trypanosomiasis.

Chagas disease

(shag'as)
[Carlos Ribeiro Justiniano Chagas, Brazilian physician, 1879–1934]
A bloodborne disease caused by Trypanosoma cruzi and transmitted by the biting of a reduviid bug. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, and facial edema. Chronic cases may be mild or asymptomatic, or may be accompanied by myocarditis, cardiomyopathy, megaesophagus, megacolon, or death.

Etiology

Chagas disease may be transmitted from person-to-person by needlestick injury, transfusion, organ donation, or during childbirth.

Synonym: American trypanosomiasis; South American trypanosomiasis See: Trypanosoma cruzi

Chagas,

Carlos J.R., Brazilian physician and parasitologist, 1879-1934.
Chagas disease - parasitic infection transmitted by certain species of reduviid (triatomine) bugs. Synonym(s): Chagas-Cruz disease; Chagas-Mazza disease; Cruz trypanosomiasis; South American trypanosomiasis
Chagas-Cruz disease - Synonym(s): Chagas disease
Chagas-Mazza disease - Synonym(s): Chagas disease

Mazza,

Salvador, Argentinian physician, 1886-1946.
Chagas-Mazza disease - Synonym(s): Chagas disease
References in periodicals archive ?
Several cardiovascular signaling routes have been shown to participate in the pathophysiology of Chagas cardiomyopathy (Huang et al.
Therefore, the potent anti-inflammatory and cardioprotective actions, low cost, advantageous oral administration and outstanding safety profile evidenced by Cur deserve consideration as a complementary tool to the limited array of therapies so far available for treatment of Chagas cardiomyopathy.
Meymandi, whose earlier research established that Chagas cardiomyopathy carries significantly higher morbidity and mortality than does non-Chagas cardiomyopathy (Circulation.
Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors.
The other cardiomyopathies, like Chagas cardiomyopathy and postpartum cardio-myopathy, can be regarded as a group of secondary heart muscle diseases.
In detail, significantly more patients with measurable HS cTnT (>LLD), or even values greater than the 99th percentile, were seen in the group with Chagas cardiomyopathy compared with the healthy controls, the patients in the indeterminate stage, and the patients in the megacolon group.
23,24) Recurring inflammation episodes, combined with focal inflammation areas in the heart, are typical in Chagas cardiomyopathy.
Three patients with negative serologic findings and positive PCR results had clinical signs and symptoms that suggested Chagas cardiomyopathy.
We also observed that some of these persons had cardiac abnormalities suggestive of Chagas cardiomyopathy.
After three dogs died from acute Chagas cardiomyopathy at one location, an investigation was conducted of the home, garage, and grounds of the owner.