cervical intraepithelial neoplasia

neoplasia /neo·pla·sia/ (-pla´zhah) the formation of a neoplasm.

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cervical intraepithelial neoplasia  (CIN) dysplasia of the cervical epithelium, often premalignant, characterized by various degrees of hyperplasia, abnormal keratinization, and the presence of condylomata.

gestational trophoblastic neoplasia  (GTN) a group of neoplastic disorders that originate in the placenta, including hydatidiform mole, chorioadenoma destruens, and choriocarcinoma.

multiple endocrine neoplasia  (MEN) a group of rare diseases caused by genetic defects that lead to hyperplasia and hyperfunction of two or more components of the endocrine system; type I is characterized by tumors of the pituitary, parathyroid glands, and pancreatic islet cells, with peptic ulcers and sometimes Zollinger-Ellison syndrome; type II is characterized by thyroid medullary carcinoma, pheochromocytoma, and parathyroid hyperplasia; type III is similar to type II but includes neuromas of the oral region, neurofibromas, ganglioneuromas of the gastrointestinal tract, and café-au-lait spots.

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cervical in·tra·ep·i·the·li·al neoplasia (ntr-p-thl-l)

n.

Dysplastic changes beginning at the squamocolumnar junction in the uterine cervix that may be precursor to squamous cell carcinoma.

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Cervical intraepithelial neoplasia (CIN)

A term used to categorize degrees of dysplasia arising in the epithelium, or outer layer, of the cervix.

Mentioned in: Cervical Cancer, Pap Test

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cervical intraepithelial neoplasia (CIN)

[in′trə·ep′ithē′lē·əl]

abnormal changes in the basal layers of the squamous epithelial tissues of the uterus. The disorder is graded according to its pathologic progress, from CIN1 to CIN3; CIN3 represents carcinoma of the cervix. The disorder is associated with human papillomaviruses.

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cervical intraepithelial neoplasia

Cervical dysplasia, CIN Gynecology Precancerous change of uterine cervical epithelium Screening Pap smears, colposcopy and pelvic exam Peak age 25 to 35 Risk factors Multiple sexual partners, early onset of sexual activity–< age 18, early childbearing–< age 16, Hx of STDs–eg, genital warts, genital herpes, HIV; CIN represents a continuum of histologic changes ranging from CIN 1–formerly, mild dysplasia, to severe dysplasia/carcinoma in situ, CIN 3; the lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive SCC, a tendency that is enhanced by concomitant HPV infection, of which HPV 6 and 11 are associated with the 'garden variety', ie benign condylomas; HPV types 16, 18 occur in CIN 3; types 31, 33, 35, 52, 56 also occur in CIN; 78% of ♀ who are positive for HPV, especially HPV 16 and 18, eventually develop CIN 2-3 Treatment Cone biopsy, laser vaporization or excision, loop electrosurgical excision, cryotherapy. See Carcinoma-in-situ, Cervical cancer, Intraepithelial neoplasia, Dysplasia, Low-grade intraepithelial neoplasia, High-grade intraepithelial neoplasia

Progression of Cervical Intraepithelial Neoplasia

	CIN 1	CIN 2	CIN 3
Regression	60%/50%	40%/43%	33%/–
Persistence	30%/41%	40%/48%	55%/–
Progression to CIN 3	10%/9%	20%/9%	NA
Progression to SCC	± 1%	5%	≥ 12%

From Int J Gynecol Pathol 1993; 12:186/Modern Pathol 1990; 3:679.