BAP1

(redirected from Cerebral protein 6)

BAP1

A gene on chromosome 3p21.31-p21.2 that encodes a tumour-suppressing enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. BAP1 forms the catalytic component of the PR-DUB complex, which specifically mediates deubiquitination of histone H2A monoubiquitinated at “Lys-119”. BAP1 is also a less preferred gene symbol for what is now designated as MAGI1, see there.