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central pontine myelinolysis |
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central pontine myelinolysis Neuropathology A condition characterized by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatremia; first identified in
alcoholics–Wernicke-Korsakoff syndrome, CPM also occurs in AIDS, infection, lymphoproliferative disorders–eg, AML, malnutrition, and venous obstruction Clinical Weakness, double vision, muscle spasms, speech defects, delirium, sleep
disorders, hallucinations, tremors and uncontrolled eye movements Imaging Defects are seen by MRI Prevention Slow correction of electrolytic imbalance How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Osmotic demyelination, or central pontine myelinolysis, in association with the rapid correction of an acute hyponatremia (ie, <48 hour duration), has not been reported (86) and should never be an impediment to rapidly correcting hyponatremia in symptomatic EAH (7,21-23,26,43,46,54,60). |
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