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cell membrane |
Also found in: Encyclopedia, Wikipedia, Hutchinson | 0.04 sec. |
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In a cellular membrane, the water-attracting groups, which are exposed to the aqueous cellular environment, sandwich an inner core of water-repelling tails. Lipid damage in the cellular membrane then leads to calcium leakage from internal sites in the cell, triggering the second step: an increase in the synthesis of the free radical nitric oxide. Agents like pentafuside (T-20) and its likely successor, T-1249, act by interfering with the so-called "hairpin" mechanism of one of HIV's proteins, which unfolds in a hinged fashion, extends itself to harpoon the cell membrane and then coils back onto itself to bring the virus close to the cellular membrane. |
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