cell adhesion molecule

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cell ad·he·sion mol·e·cule (CAM),

proteins that hold cells together, for example, uvomorulin, and hold them to their substrates, for example, laminin.

cell ad·he·sion mol·e·cule

(CAM) (sel ad-hē'zhŭn mol'ĕ-kyūl)
Proteins that hold cells together, e.g., uvomorulin, and hold them to their substrates, e.g., laminin.

cell adhesion molecule

,

CAM

Any molecule that traverses the cell membrane and contains a chemical domain that binds it to other cells or to the extracellular matrix.
References in periodicals archive ?
Association of circulating cellular adhesion molecules with menopausal status and hormone replacement therapy: time-dependent change in transdermal, but not oral estrogen users.
Intercellular adhesion molecule-1 (ICAM-1) and E-, P-, and L-selectin are cellular adhesion molecules involved in the recruitment of leukocytes on the activated vessel wall during inflammation (1) and play an important role in the early stages of atherosclerosis and its complications (2).
For example, cytokines stimulate collagen synthesis in smooth muscle cells and promote endothelial and vascular smooth muscle cell activation through the induction of cellular adhesion molecules.
Because cellular adhesion molecules such as VCAM-1, intercellular adhesion molecule-1, and E-selectin and many cytokines and growth factors such as M-CSF contain functional DNA-binding sequences for NF-[kappa]B, AP-1, and egr-1, their expression is induced by the activation of these transcription factors (84).
Thus, antioxidants may protect against the development of atherosclerotis by inhibiting the activation of pro-inflammatory transcription factors that are required for the induction of cellular adhesion molecules, cytokines, and growth factors in the vessel wall.
Endothelium-derived NO inhibits the expression of cellular adhesion molecules on the endothelial surface and thereby prevents leukocyte attachment to the vessel wall (31,103).
PS-341 has been shown to inhibit cell growth signaling pathways, induce apoptosis, and inhibit the expression of cellular adhesion molecules in vitro.
Scientists have discovered all sorts of developmental proteins, cellular adhesion molecules, growth factors and glial cells that actually support growth and play an active role in function," Ron Cohen, M.
Using a rational drug design approach, TRL's scientists are discovering new chemical compounds which inhibit specific cellular adhesion molecules involved in inflammation- related disorders.
The research collaboration will focus on the discovery and design of synthetic compounds that inhibit the interaction of cellular adhesion molecules (CAMs), such as selectins and integrins.

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