The recruitment of these inflammatory cells and their transendothelial migration is mediated by the cellular adhesion molecules
(CAMs), which are expressed by endothelial cells and circulating leukocytes (monocytes and linfocytes) in response to different inflammatory stimuli (Davies et al.
For example, cytokines stimulate collagen synthesis in smooth muscle cells and promote endothelial and vascular smooth muscle cell activation through the induction of cellular adhesion molecules.
Because cellular adhesion molecules such as VCAM-1, intercellular adhesion molecule-1, and E-selectin and many cytokines and growth factors such as M-CSF contain functional DNA-binding sequences for NF-[kappa]B, AP-1, and egr-1, their expression is induced by the activation of these transcription factors (84).
The mentioned cellular adhesion molecules
play a crucial role in the migration of leucocytes from the blood to the arterial intima (transendothelial route).
Association of circulating cellular adhesion molecules
with menopausal status and hormone replacement therapy: time-dependent change in transdermal, but not oral estrogen users.
Host defenses to extravascular infections usually elicit proinflammatory cytokines and stimulate increased expression of cellular adhesion molecules
, enhancing leukocyte adhesion.
If future studies confirm our results, cellular adhesion molecules
may be potential targets to prevent restenosis in clinical practice.
This process is mediated by cellular adhesion molecules
such as sE-selectin, a specific product of endothelial cells.
Cytokine-induced expression of cellular adhesion molecules
was measured on primary human coronary artery endothelial cell (HCAEC) cultures.
Intercellular adhesion molecule-1 (ICAM-1) and E-, P-, and L-selectin are cellular adhesion molecules
involved in the recruitment of leukocytes on the activated vessel wall during inflammation (1) and play an important role in the early stages of atherosclerosis and its complications (2).
The new research, she says, "has the implication that other cellular adhesion molecules
may well be major receptors for other, much more pathogenic viruses.
The effects of acute psychological stress on cellular adhesion molecules