Sertoli cell

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Sertoli cell

(sər-tō′lē, sĕr-)
n.
Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.

Sertoli cell

[sertō′lē]
Etymology: Enrico Sertoli, Italian histologist, 1842-1910; L, cella, storeroom
one of the supporting elongated cells of the seminiferous tubules of the testes. It functions to nourish the developing spermatocytes.

Sertoli cell

An elongated cell in the seminiferous tubules of the testis which secretes sex hormone-binding globulin and provides a micro-environment for developing sperm.

Sertoli cells secretions
• Anti-Müllerian hormone—Early foetal life.
• Inhibin and activins—Post-pubertal; regulate FSH secretion.
• Androgen binding protein—Concentrates testosterone in the seminiferous tubules, stimulating spermiogenesis.
• Oestradiol aromatase—Converts testosterone to 17 beta oestradiol for spermatogenesis.
• Glial cell-derived neurotrophic factor—Drives spermatogonial stem cell renewal during perinatal period.
• ERM transcription factor—Maintains spermatogonial stem cell in the adult testis.
• Transferrin—Iron ion delivery.

Sertoli cell

any of the elongated cells in the tubules of the testes to which the spermatids become attached; they provide support, protection and, apparently, nutrition until the spermatids are transformed into mature spermatozoa.

ovarian Sertoli cell tumor
Sertoli-Leydig tumor of an atopic ovary in a bitch, commonly associated with cystic endometrial hyperplasia.
testicular Sertoli cell tumor
occurs most commonly in dogs, particularly in retained testicles. Production of estrogen may cause feminization in which the dog is attractive to other males with reduced libido, feminine distribution of body fat, symmetrical alopecia, atrophy of the penis, increased size of the mammary glands and prepuce, and prostatic enlargement. Rarely there is depression of bone marrow activity with anemia, thrombocytopenia and granulocytopenia.