cell-mediated immunity

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cell-·me·di·at·ed im·mu·ni·ty (CMI),

, cellular immunity
Immune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory response and cellular recruitment through their secretion of cytokines and chemokines.
Synonym(s): delayed hypersensitivity (1)

cell-mediated immunity

Immunity resulting from a cell-mediated immune response. Also called cellular immunity.

cell-mediated immunity

cell-me·di·at·ed im·mu·ni·ty

, cellular immunity (CMI) (sel'mē'dē-āt-ĕd i-myū'ni-tē, sel'yū-lăr)
Immune responses that are initiated by T lymphocytes and mediated by T lymphocytes, macrophages, or both (e.g., graft rejection, delayed-type hypersensitivity).
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cell-mediated immunity

Abbreviation: CMI.
The regulatory and cytotoxic activities of T cells during the specific immune response. This process requires about 36 hr to reach its full effect. Synonym: T-cell–mediated immunity See: illustration; humoral immunity

Unlike B cells, T cells cannot recognize foreign antigens on their own. Foreign antigens are recognized by antigen-presenting cells (APCs) such as macrophages, which engulf them and display part of the antigens on the APC's surface next to a histocompatibility or “self-” antigen (macrophage processing). The presence of these two markers, plus the cytokine interleukin-1 (IL-1) secreted by the APCs activates CD4 helper T cells (TH cells), which regulate the activities of other cells involved in the immune response.

CMI includes direct lysis of target cells by cytotoxic T cells, creation of memory cells that trigger a rapid response when a foreign antigen is encountered for the second time, and delayed hypersensitivity to tissue and organ transplants. T cells also stimulate the activity of macrophages, B cells, and natural killer cells. These functions are controlled largely by the secretion of lymphokines such as the interleukins, interferons, and colony-stimulating factors. Lymphokines facilitate communication and proliferation of the cells in the immune system.

See also: immunity

cell-mediated immunity

Action by the immune system involving T cells (T LYMPHOCYTES) and concerned with protection against viruses, fungi, TUBERCULOSIS and cancers and rejection of foreign grafted material. Cell-mediated immunity is not primarily effected by ANTIBODIES.


effected by cellular rather than chemical elements.

cell-mediated hypersensitivity
see delayed hypersensitivity.
cell-mediated immunity
see cellular immunity.
cell-mediated lympholysis assay
a test of cell-mediated immunity in which activated cytoxic T lymphocytes cause lysis of 51Cr-labeled target cells.
References in periodicals archive ?
Effects of colchicine on cell mediated immunity (CMI): Experimental animals: Albino mice (five-to-seven week-old) were purchased from Department of Theriogenolgy University of Veterinary and Animal Sciences (UVAS) Lahore.
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Cell mediated immunity and lower genital tract neoplasia.
In conclusion, flurbiprofen decreased both humoral and cell mediated immunity in mice.
Since BCG vaccination is known to stimulate cell mediated immunity, which in turn would raise the ADA levels, it was suggested that ADA levels could indicate successful BCG vaccination.
10, 11] Therefore ADA has been considered as a marker of cell mediated immunity.
In a study done by Sajid et al 2007, on rabbits, the cell mediated immunity against dinitrochlorobenzene (DNCB) was determined by delayed-type hypersensitivity.
NeuroVax(TM) has been shown to stimulate strong disease specific cell mediated immunity in nearly all patients treated and appears to work by enhancing levels of FOXP3+ Treg cells that are able to down regulate the activity of pathogenic T-cells that cause MS.
announced today that results of a clinical trial on rhesus macaque monkeys infected with the Simian Immunodeficiency Virus (SIV) established that the Company's ultraviolet light technology was safe and effective in increasing cell mediated immunity against the virus and in reducing viral load.
A of Oslo, Norway for Dynal Biotech to supply Dynabeads(R) to Cylex for use in conjunction with Cylex's patented(a) In Vitro CMI(TM) technology for the measurement of cell mediated immunity.
Anderson on eventual sales of the Company's products developed using the licensed subject matter, (3) granted rights to additional patents and patent applications pertaining to licensed subject matter specifically in the field of cell mediated immunity inducing HIV vaccine, and (4) given a right of first refusal to license any technology developed by the scientists and labs covered in the original Patent and Technology License Agreement in the fields of both antiviral and anticancer research.