CDK2

(redirected from Cell division protein kinase 2)

CDK2

A gene on chromosome 12q13 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is essential for G1/S phase transition in the cell cycle. CDK2 associates with, and is regulated by, the regulatory subunits of the complex (cyclin A or E), CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B); its activity is regulated by phosphorylation.
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