RCC1

(redirected from Cell cycle regulatory protein)

RCC1

A gene on chromosome 1p36.1 that encodes a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. The RCC1 protein product helps regulate the onset of S-phase chromosome condensation, binding to nucleosomes and double-stranded DNA. The RCC1-Ran complex with other proteins is part of a signal transmission pathway that detects unreplicated DNA. RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
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The CINtec([R]) PLUS kit detects and stains for two biomarkers: the multiply validated cell cycle regulatory protein p16INK4a (p16) and Ki-67, a marker of active cell proliferation.
ABT-578 is designed to inhibit smooth muscle cell proliferation -- a key contributor to restenosis or the reclogging of arteries -- by blocking the function of the cell cycle regulatory protein, mTOR.
Differential effects of cell cycle regulatory protein [p21.
4A, wild type cells exhibited increased expression of the cell cycle regulatory proteins p53 and p21 after 48 hours exposure to 1.
ABT-578, the active drug released from the polymer-coated stent, is designed to inhibit smooth muscle cell proliferation--a key contributor to restenosis or the reclogging of arteries--by blocking the function of the cell cycle regulatory protein, mTOR.
This MCE blockade was caused apparently by decreased phosphorylation of C/EBP[beta], modulation in expression of cell cycle regulatory proteins, and upregulation of Wnt/[beta]-catenin pathway, the early stage regulatory proteins of adipogenic induction.
To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin D1) in the differential diagnosis of mammary vascular lesions.
In tumor cells, proteasome inhibition produces overwhelming cellular stress by stabilizing cell cycle regulatory proteins and disrupting cell proliferation, ultimately leading to apoptosis (cell death).
The effect of ARG on the expression of cell cycle regulatory proteins
Suprabasal expression of the human papillomavirus type 16 oncoproteins in mouse epidermis alters expression of cell cycle regulatory proteins.
The results suggest that maslinic acid induces G1 cell cycle arrest with induction of Gl phase cell cycle regulatory proteins p21 and the degradation of cyclin Dl, and inhibits nuclear NF-kB (p65) activity.

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