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Related to Celestone: Celestone Soluspan

betamethasone (systemic)

(bay-ta-meth-a-sone) ,


(trade name),


(trade name)


Therapeutic: anti inflammatories steroidal
Pharmacologic: corticosteroids
Pregnancy Category: C


Management of adrenocortical insufficiency; chronic use in other situations is limited because of mineralocorticoid activity.Used systemically and locally in a wide variety of chronic diseases including:
  • Inflammatory,
  • Allergic,
  • Hematologic,
  • Neoplastic,
  • Autoimmune disorders.
Replacement therapy in adrenal insufficiency.Short-term administration to high-risk mothers before delivery to prevent respiratory distress syndrome in the newborn.


In pharmacologic doses, suppresses inflammation and the normal immune response.
Has numerous intense metabolic effects (see Adverse Reactions and Side Effects).
Suppresses adrenal function at chronic doses of 0.6 mg/day.
Has negligible mineralocorticoid activity.

Therapeutic effects

Suppression of inflammation and modification of the normal immune response.
Replacement therapy in adrenal insufficiency.


Absorption: Sodium phosphate salt is rapidly absorbed after IM administration. Acetate salt is slowly but completely absorbed after IM administration. Absorption from local sites (intra-articular, intralesional) is slow but complete.
Distribution: Widely distributed; crosses the placenta and probably enters breast milk.
Metabolism and Excretion: Metabolized mostly by the liver.
Half-life: 3–5 hr (plasma), 36–54 hr (tissue); adrenal suppression lasts 3.25 days.

Time/action profile (anti-inflammatory activity)

IM (sodium phosphate/acetate)1–3 hrunknown1 wk


Contraindicated in: Active untreated infections (may be used in patients being treated for tuberculous meningitis); Traumatic brain injury (high doses may ↑ mortality); Lactation: Avoid chronic use; Some products contain bisulfites and should be avoided in patients with known hypersensitivity.
Use Cautiously in: Chronic treatment (will lead to adrenal suppression; use lowest possible dose for shortest period of time); Hypothyroidism; Cirrhosis; Ulcerative colitis; Stress (surgery, infections); supplemental doses may be needed; Potential infections may mask signs (fever, inflammation); Obstetric: Safety not established; Pediatric: Chronic use will result in ↓ growth; use lowest possible dose for shortest period of time.

Adverse Reactions/Side Effects

Adverse reactions/side effects are much more common with high-dose/long-term therapy

Central nervous system

  • depression (most frequent)
  • euphoria (most frequent)
  • headache
  • ↑ intracranial pressure (children only)
  • personality changes
  • psychoses
  • restlessness

Ear, Eye, Nose, Throat

  • cataracts
  • ↑ intraocular pressure


  • hypertension (most frequent)


  • peptic ulceration (life-threatening)
  • anorexia (most frequent)
  • nausea (most frequent)
  • vomiting


  • acne (most frequent)
  • ↓ wound healing (most frequent)
  • ecchymoses (most frequent)
  • fragility (most frequent)
  • hirsutism (most frequent)
  • petechiae (most frequent)


  • adrenal suppression (most frequent)
  • hyperglycemia

Fluid and Electrolyte

  • fluid retention (long-term high doses)
  • hypokalemia
  • hypokalemic alkalosis


  • thromboembolism (life-threatening)
  • thrombophlebitis


  • weight gain
  • weight loss


  • muscle wasting (most frequent)
  • osteoporosis (most frequent)
  • avascular necrosis of joints
  • muscle pain


  • cushingoid appearance (moon face, buffalo hump) (most frequent)
  • ↑ susceptibility to infection


Drug-Drug interaction

Additive hypokalemia withthiazide and loopdiuretics, or amphotericin B.Hypokalemia may ↑ risk of digitalis glycoside toxicity.May ↑ requirement for insulins or oral hypoglycemic agents.Phenytoin,phenobarbital, and rifampin stimulate metabolism; may ↓ effectiveness. Oral contraceptives may block metabolism.↑ risk of adverse GI effects with NSAIDs (including aspirin).At chronic doses that suppress adrenal function, may ↓ antibody response to and ↑ risk of adverse reactions from live-virus vaccines.


Intramuscular (Adults) 0.5–9 mg/day as betamethasone sodium phosphate/acetate suspension in 1–2 divided doses. Prevention of respiratory distress syndrome in newborn—12 mg daily for 2–3 days before delivery (unlabeled).
Intramuscular (Children) Adrenocortical insufficiency—17.5 mcg/kg (500 mcg/m2)/day in 3 divided doses every 3rd day or 5.8–8.75 mcg/kg (166–250 mcg/m2)/day as a single dose. Other uses—20.8–125 mcg/kg (0.625–3.75 mg/m2) of the base q 12–24 hr.

Availability (generic available)

Suspension for injection (sodium phosphate and acetate): 6 mg (total)/mL

Nursing implications

Nursing assessment

  • Indicated for many conditions. Assess involved systems before and periodically during therapy.
  • Assess patient for signs of adrenal insufficiency (hypotension, weight loss, weakness, nausea, vomiting, anorexia, lethargy, confusion, restlessness) before and periodically during therapy.
  • Monitor intake and output ratios and daily weights. Observe patient for peripheral edema, steady weight gain, rales/crackles, or dyspnea. Notify health care professional if these occur.
  • Pediatric: Children should have periodic growth evaluations.
  • Lab Test Considerations: Monitor serum electrolytes and glucose. May cause hyperglycemia, especially in persons with diabetes. May cause hypokalemia. Patients on prolonged courses of therapy should routinely have hematologic values, serum electrolytes, and serum glucose evaluated. May ↓ WBC counts. May ↓ serum potassium and calcium and ↑ serum sodium concentrations.
    • Guaiac-test stools. Promptly report presence of guaiac-positive stools.
    • May ↑ serum cholesterol and lipid values. May decrease uptake of thyroid 123I or 131I.
    • Suppress reactions to allergy skin tests.
    • Periodic adrenal function tests may be ordered to assess degree of hypothalamic-pituitary-adrenal axis suppression in systemic and chronic topical therapy.

Potential Nursing Diagnoses

Risk for infection (Side Effects)
Disturbed body image (Side Effects)


  • If dose is ordered daily or every other day, administer in the morning to coincide with the body’s normal secretion of cortisol.
  • Intramuscular: Shake suspension well before drawing up. Do not dilute with other solution or admix. Do not administer suspensions IV.

Patient/Family Teaching

  • Stopping the medication suddenly may result in adrenal insufficiency (anorexia, nausea, weakness, fatigue, dyspnea, hypotension, hypoglycemia). If these signs appear, notify health care professional immediately. This can be life-threatening.
    • Glucocorticoids cause immunosuppression and may mask symptoms of infection. Instruct patient to avoid people with known contagious illnesses and to report possible infections immediately.
    • Caution patient to avoid vaccinations without first consulting health care professional.
    • Review side effects with patient. Instruct patient to inform health care professional promptly if severe abdominal pain or tarry stools occurPatient should also report unusual swelling, weight gain, tiredness, bone pain, bruising, nonhealing sores, visual disturbances, or behavior changes.
    • Advise patient to notify health care professional of medication regimen before treatment or surgery.
    • Discuss possible effects on body image. Explore coping mechanisms.
    • Instruct patient to inform health care professional if symptoms of underlying disease return or worsen.
    • Advise patient to carry identification describing disease process and medication regimen in the event of an emergency in which patient cannot relate medical history.
    • Explain need for continued medical follow-up to assess effectiveness and possible side effects of medication. Periodic lab tests and eye exams may be needed.
  • Long-term Therapy: Encourage patient to eat a diet high in protein, calcium, and potassium, and low in sodium and carbohydrates (see ). Alcohol should be avoided during therapy.

Evaluation/Desired Outcomes

  • Decrease in presenting symptoms with minimal systemic side effects.
  • Suppression of the inflammatory and immune responses in autoimmune disorders, allergic reactions, and neoplasms.
  • Management of symptoms in adrenal insufficiency.


a trademark for a glucocorticoid (betamethasone).


A trade name for BETAMETHASONE.
References in periodicals archive ?
The literature is conflicting as to whether Kenalog or Celestone is better for pain relief, (62,63) with some suggesting that the crystallization of Kenalog provides better long-term benefit (62) and others noting that the soluble properties of Celestone provide quicker onset of action.
Efficacy of epidural injections of Kenalog and Celestone in the treatment of lower back pain.
Making things still worse, requests for Schering Plough's brand name formulation of betamethasone, Celestone, a well-studied alternative to dexamethasone, are also on back order, according to a company spokesperson.
based manufacturer of Celestone Soluspan, has requested that hospitals conserve their supplies of the injectable steroid for prenatal use only.
Making things still worse, re quests for Schering-Plough's brand name formulation of betamethasone, Celestone, a well-studied al ternative to dexamethasone, are also on back order, according to a company spokesperson.