cefepime

cefepime /cef·e·pime/ (sef´ĕpēm) a fourth-generation cephalosporin antibiotic; used as the hydrochloride salt.

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cefepime,

a fourth-generation cephalosporin.

indications It is used to treat infections caused by gram-negative bacilli, including Escherichia coli, Proteus, and Klebsiella; gram-positive organisms, including Streptococcus pneumoniae, S. pyogenes, and Staphylococcus aureus; and infections of the lower respiratory tract, urinary tract, skin, and bone.

contraindications Known hypersensitivity to cephalosporins prohibits its use. It also should not be used in infants less than one month old.

adverse effects Life-threatening effects include nephrotoxicity, renal failure, leukopenia, thrombocytopenia, agranulocytosis, neutropenia, lymphocytosis, eosinophilia, pancytopenia, hemolytic anemia (rare), and anaphylaxis. Other serious effects include GI bleeding; increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, lactic dehydrogenase, and alkaline phosphatase; proteinuria, candidiasis, increased blood urea nitrogen, and thrombophlebitis. Common side effects include nausea, vomiting, diarrhea, and anorexia.

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cefepime (sef´pēm),

n brand name: Maxipime;
drug class: fourth-generation cephalosporin;
action: inhibits cell wall synthesis in sensitive organisms and is bactericidal;
uses: respiratory tract, urinary tract, and skin and other soft tissue infections associated with gram-negative organisms.

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cefepime

a fourth generation cephalosporin antibiotic.

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cefepime

Maxipime^® Infectious disease A 4^th-generation cephalosporin Indications RTIs–eg bronchitis, pneumonia; cellulitis and other skin and soft-tissue infections; UTIs–eg pyelonephritis, febrile neutropenia, PID, gonorrhea, septicemia, intra-abdominal infections, meningitis, surgical prophylaxis. See Cephalosporin.