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Cedax |
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Cedax, a trademark for an oral cephalosporin (ceftibuten). ceftibuten Cedax Pharmacologic class: Third-generation cephalosporin Therapeutic class: Anti-infective Pregnancy risk category B ActionInterferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity. AvailabilityCapsules: 400 mg Oral suspension: 90 mg/5 ml, 180 mg/5 ml ⊘Indications and dosages ➣ Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae; pharyngitis and tonsillitis caused by Streptococcus pyogenes; acute bacterial otitis media caused by H. influenzae, M. catarrhalis, and S. pyogenes Adults and children ages 12 and older: 400 mg P.O. q 24 hours for 10 days Children ages 12 and younger: 9 mg/kg P.O. daily for 10 days. Maximum dosage shouldn't exceed 400 mg daily. Dosage adjustment• Renal impairment Off-label uses• Urinary tract infections Contraindications• Hypersensitivity to cephalosporins and penicillins PrecautionsUse cautiously in: Administration• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.
Adverse reactionsCNS: headache, lethargy, paresthesia, syncope, seizures CV: hypotension, palpitations, chest pain, vasodilation EENT: hearing loss GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis GU: vaginal candidiasis, nephrotoxicity Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression Hepatic: hepatic failure, hepatomegaly Musculoskeletal: arthralgia Respiratory: dyspnea Skin: urticaria, easy bruising, maculopapular or erythematous rash Other: chills, fever, superinfection, anaphylaxis, serum sickness InteractionsDrug-drug. Aminoglycosides, loop diuretics: increased risk of nephrotoxicity Probenecid: decreased excretion and increased blood level of ceftibuten Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results Hemoglobin, platelets, white blood cells: decreased values Drug-herbs. Angelica, anise, arnica, asafetida, bogbean, boldo, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, horseradish, licorice, meadowsweet, onion, papain, passionflower, poplar, prickly ash, quassia, red clover, turmeric, wild carrot, wild lettuce, willow: increased risk of bleeding Patient monitoring• Assess CBC and kidney and liver function test results. Patient teaching• Instruct patient to take oral suspension at least 1 hour before or 2 hours after a meal. Cedax® Ceftibuten, see there Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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