CDX2


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CDX2

A gene on chromosome 13q12.3 that encodes a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates its transcription. CDX regulates the transcription of multiple genes expressed in the intestinal epithelium, both during early differentiation and as part of the maintenance of the intestinal epithelial lining of the small and large intestines.

CDX2

A gut protein used clinically in immunocytochemistry to identify adenocarcinomas of the colon and other tissues and tumors of intestinal origin.
References in periodicals archive ?
Immunophenotypic analysis revealed positive expression of Cytokeratin (CK) 20 and CDX2 which was compatible with appendiceal primary and ovarian metastases.
The protocol is designed to mimic natural embryonic development, and CDX2 is a molecular marker found in gut tissues.
Mouse anti-human cdx2, Dak-cdx2 clone, Ready for use; Polycl.
39) In addition, the malignancy may show an enteric immunophenotype with at least focal positivity for CDX2 and/or CK20.
Immunohistochemistry staining of the tumor for CK7, CK20, and CDX2 can also be employed to help make this determination.
91) Thus, as expected, expression of Cdx2 was significantly higher in human gastric cancer mucosa than in non-cancerous mucosa.
in tumour cells and negativity for PSA, AMACR, and CDX2 in paraffin section helped in identifying the tumour as primary in the urinary bladder.
Immunohistochemistry showed tumor positivity for vimentin, smooth-muscle actin and synaptophysin and negativity for the keratin 7, keratin AE1/AE3, keratin 20, keratin 5/6, chromogranin, KIT (CD117), CD34, CDX2, CD56, protein-S100, p63 and desmin antigens (Figures 5 and 6).
CDX2 VDR Polymorphism and Colorectal Cancer,"Cancer Epidemiol.
pylori] inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition andMUC2 gene induction," elaborated Dr.
Re-activate a colon tumor suppressor gene, CDX2, which is deactivated early in the process of colon carcinogenesis.
Kannagi, "Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition," Proceedings of the National Academy of Sciences of the United States of America, vol.