CDK2


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CDK2

A gene on chromosome 12q13 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is essential for G1/S phase transition in the cell cycle. CDK2 associates with, and is regulated by, the regulatory subunits of the complex (cyclin A or E), CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B); its activity is regulated by phosphorylation.
References in periodicals archive ?
2] value between CDK2 and RBL1 in 4 RNA samples is around 0.
Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.
Outro possivel mecanismo de acao e a inibicao da adipogenese pela EGCG devido ao seu envolvimento com a modulacao mitotica da proteina quinase (MAP), especialmente em sinais regulatorios extracelulares (ERK), que estimulam o fator de crescimento e a via CDK2, enzima chave para o processo da mitogenese.
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Ciplmediated inhibition of cdk2.
Paraffin-embedded specimens from inactive endometrium (n = 16), endometrial hyperplasia (n = 23) and endometrioid endometrial carcinoma (n = 39) were stained immunohistochemically for cyclin A, cyclin B1, cyclin D1, cyclin E, cdk2, p16, p21, p27, p53 and Ki67(MIB-1).
More necently, erythrosin B (dose range: 25-100 [micro]g/mL) has been shown to stimulate proliferation in estrogen receptor (ER) positive HTB 133 cells and to increase Cdk2 activity (dose range: 3-10 [micro]g/mL) in MCF7 cells (Dees et al.
Estudios preclinicos han demostrado la eficacia del mifepristone para inhibir el crecimiento del cancer epitelial de ovario, a traves de la activacion de inhibidores de la ciclina dependiente de quinasa (cdk) y la reducida trascripcion de factores que expresan cdk2 y ciclinas A y E.
Um possivel mecanismo de acao e a epigalocatequina galato induzindo a inibicao da adipogenese pode estar envolvido com a modulacao mitotica da proteina quinase (MAP), especialmente sinais regulatorios extracelulares (ERK) que estimulam fatores de crescimento e da via Cdk2, tambem enzima chave para o processo de mitogenese (Lin e colaboradores, 2005; Hung e colaboradores, 2005).
Morgan and Sung-Hou Kim of the University of California at Berkeley had previously determined the structure of CDK2.
Martell served as Vice President and Chief Medical Officer of MethylGene, a publicly-traded biotechnology company focused on the development of cancer therapeutics, and as Director of Oncology Global Clinical Research at Bristol-Myers Squibb Company, where he worked with molecular-targeted drugs in areas such as multi-target kinase inhibitors (including the panHER inhibitor program), CDK2 inhibitor and was closely involved in the Biologic Licensing Application (BLA) for Erbitux, an antibody that targets EGFR.
We observed that berberine treatment significantly decreased the expression of cydin D1, cydin E, CDK2, and CDK4 (cydin dependent kinases).