Clostridium difficile

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Clos·trid·i·um dif·fi·cile

Avoid the mispronunciation dĭf-ĭ-sēl' of this Latin word, which is correctly pronounced dĭ-fĭs'ĭ-lē.
a bacterial species found in feces of humans and animals. It colonizes newborn infants, who are spared from toxin-induced diarrheal disease. Pathogenic for human beings, guinea pigs, and rabbits; frequent cause of colitis and diarrhea following antibiotic use. Found to be a cause of pseudomembranous colitis and associated with a number of intestinal diseases that are linked to antibiotic therapy; also the chief cause of nosocomial diarrhea.
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Clostridium difficile

(dĭf′ĭ-sēl′, dĭf′ĭ-sēl′, dĭf′ĭ-kē′lā)
n.
A bacterium that causes an infectious form of severe diarrhea especially in elderly people on antibiotic therapy and in hospitalized patients. Also called C. diff..

Clostridium difficile

[difis′ilē]
A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis in persons receiving antibiotic therapy causing watery diarrhea. The species affects guinea pigs and rabbits as well as humans.

Clostridium difficile

A common cause of bacterial colitis; it is the causative agent in 99% of pseudomembranous colitis, and 20-30% of antibiotic-associated diarrhea

Clos·trid·i·um dif·fi·ci·le

(klos-trid'ē-ŭm di-fis'i-lē)
Gram-positive obligate anaerobic or microaerophilic, rod-shaped bacterium; causes sometimes severe antibiotic-associated colitis.
Synonym(s): C-Diff, CDT.
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Clostridium difficile

A fecal organism endemic in hospitals and responsible for the majority of hospital-acquired cases of diarrhoea in elderly patients. Its prevalence in hospital is largely due to the high levels of antibiotic usage. Bowel infection can be cleared by oral treatment with the antibiotic vancomycin which is not appreciably absorbed into the bloodstream. Up to 40 percent of hospitalized patients are colonized with this organism. Only about 3 percent of healthy adults carry it. A previously uncommon strain with variations in toxin genes has emerged as a cause of C. difficile -associated disease.

Clostridium

a genus of anaerobic spore-forming bacteria of the family Bacillaceae. Most are gram-positive rods.

Clostridium bifermentans, Clostridium sordelli
see malignant edema.
Clostridium botulinum
causes botulism from neurotoxin produced during vegetative growth. C. botulinum types B, C and D are associated with disease in animals but the type prevalence varies geographically. See botulism.
Clostridium butyricum
involved in the spoilage of meat.
Clostridium cadaveris
may be associated with colitis X in horses.
Clostridium chauvoei
formerly called C. feseri. See blackleg.
Clostridium colinum
cause of ulcerative enteritis and liver necrosis in quail, turkeys, grouse, partridge and chickens. Not an accredited species.
Clostridium difficile
see antibiotic-associated colitis.
Clostridium feseri
now called C. chauvoei (above).
Clostridium haemolyticum
formerly called C. novyi type D. See bacillary hemoglobinuria.
Clostridium histolyticum
a species found in feces, soil and sometimes wound infections. An important cause of meat spoilage.
Clostridium nigrificans
a thermophilic spoiler of canned meat producing hydrogen sulfide gas and causing purple staining of the inside of the can. Now called Desulfotomaculum nigrificans.
Clostridium novyi
see infectious necrotic hepatitis. See also C. haemolyticum (above). Previously called C. oedematiens. Type A causes malignant edema in cattle and sheep, and big head in rams, type B causes infectious necrotic hepatitis (black disease), and type C has been associated with osteomyelitis in buffalo.
Clostridium overgrowth
see bacterial overgrowth.
Clostridium parabotulinum
a proteolytic subgroup of C. botulinum; not a valid species.
Clostridium perfringens
cause of enterotoxemia. Type A causes malignant edema, type B causes dysentery in lambs and enterotoxemia, type C causes struck in sheep and necrotic enteritis in piglets, type D causes enterotoxemia and type E causes necrotic enteritis. Previously called C. welchii.
Clostridium putrefaciens
causes deep bone taint in hams. See also C. putrificum (below).
Clostridium putrificum
a cause of bone taint in cured hams. There is no detectable abnormality on the surface of the ham.
Clostridium septicum
formerly called C. septique. See malignant edema, braxy.
Clostridium sordelli
cause of a small proportion of cases of gas gangrene in ruminants. See also abomasitis.
Clostridium spiroforme
associated with enteritis and enterocolitis in rabbits, guinea pigs and foals.
Clostridium sporogenes
an apathogenic clostridium often found in lesions of gas gangrene.
Clostridium tetani
a common inhabitant of soil and human and horse intestines, and the cause of tetanus in humans and domestic animals.
Clostridium villosum
found in fight abscesses and pleurisy in cats.
Clostridium welchii
see C. perfringens (above).
References in periodicals archive ?
CE marked under the European In Vitro Diagnostics Directive for the identification of toxigenic Clostridium difficile directly from stool specimens, the BD GeneOhm Cdiff assay targets the toxin B gene, found in toxigenic Clostriduim difficile strains.
The BD MAX Cdiff assay is a simple, easy-to-use, fully-automated method for detection of these dangerous bacteria," said Tom Polen, President, BD Diagnostics - Diagnostic Systems.
We have seen a significant reduction in the number of CDiff cases in the trust over the past few years.
The company also profited from a stronger flu season in 2013 and the FDA approvals of its BD Max Cdiff Assay in the United States, the BD ProbeTec Trichomonas Vaginalis Qx Amplified DNA Assay, and the nasopharyngeal wash, aspirate and swab in transport media specimens on the BD Veritor System for the rapid detection of respiratory syncytial virus.
Moeslein, RN, MSA, CIC, Infection Prevention Nurse Manager from Riverside Regional Medical Center, who will discuss 'Tales from the Trenches: How Our Facility Implemented and Evaluated UV Technology to Reduce MDROs and Cdiff.
PLEASANTON, California, March 19, 2014 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the CE-IVD launch of the cobas Cdiff Test for the detection of Clostridium difficile(C.
A SICK Midland patient died four days after hospital medics rejected her plea for a second test for the lethal CDiff superbug - because it was not 'cost effective'.
All discrepant stool samples with sufficient residual material maintained at -20[degrees]C were sent for supplemental testing at two outside laboratories using different commercially available PCR assays (GeneXpert C difficile/Epi assay [Cepheid Diagnostics, Sunnyvale, California] and Gene-Ohm Cdiff assay [BD Diagnostics, Franklin Lakes, New Jersey]).
Comparison of BD GeneOhm Cdiff PCR Assay and the Meridian Premier Toxins A&B for Detection of C difficile from Clinical Specimens Poster session presented at: March 2009 Annual Meeting of the Society for Healthcare Epidemiologists of America, San Diego, CA.
After thinking she had been through all she could take, Amy had another setback when she caught the superbug Cdiff.
During 2008/09 UCHW * reported 184 cases of the superbug Cdiff, less than half the number recorded during the previous year and well below its target of 311 cases.