Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells
in human immunodeficiency virus type 1 infection.
Contrary to CD4+ T lymphocytopenia described for acute CMV mononucleosis, 31 CMV asymptomatic carriers showed a normal count of CD4+ T cells
, on average 1.
At least 50,000 CD8+ T cells were acquired for the analysis by using FacsAria I flow cytometer (BD Immunocytometry Systems, San Jose, CA, USA), in all cases a greater number of CD4+ T cells
The immunophenotyping of the lymphocytes, especially CD4+ T cells
from peripheral blood is being used to assess the extent of immune dysfunction in the primary and secondary immunodeficiency, chronic infectious diseases and various cancers such as Hodgkin's disease, lymphoma, etc.
The first phase occurs during primary HIV infection and the early part of chronic infection when there is substantial depletion of memory (CCR5+) CD4+ T cells
and disruption of the structure and function of secondary lymphoid tissues, especially the gut-associated lymphoid tissue (GALT) of the intestinal tract [1-4].
Latent infection of CD4+ T cells
provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Enumeration of CD4+ T cells
constitutes an essential biological indicator in the clinical follow up of patients infected with HIV-1.
The vaccinated animals had good CTL (cytotoxic T lymphocyte) response after infection, stable CD4+ counts (T-cell counts), and CD4+ T cells
that responded specifically to the infecting virus.