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Related to CCl4: N2O3

carbon tetrachloride (CCl4)

Etymology: L, carbo + Gk, tetra, four, chloros, greenish
a colorless, volatile toxic liquid used as a solvent. CCl4 is particularly toxic to the kidneys and liver; permanent damage to these organs may result from exposure.


A chemokine encoded by CCL4 (formerly LAG1, SCYA4), located on chromosome 17q21-q23, which precipitates local inflammatory response characterised by infiltration of neutrophils. It is expressed after cell activation by mitogens (phytohemagglutinin, bacterial endotoxins or Staphylococcus aureus) and IL2, and inhibited by glucocorticoids, TGF-beta and cyclosporin A.

Normal expression
T-cells, B-cells, monocytes.

Abnormal expression
Various tumour cell lines.


References in periodicals archive ?
As of 2008, CCl4 accounted for about 11 percent of chlorine available for ozone depletion, which is not enough to alter the decreasing trend of ozone-depleting substances.
For almost a decade, scientists have debated why the observed levels of CCl4 in the atmosphere have declined slower than expectations, which are based on what is known about how the compound is destroyed by solar radiation and other natural processes.
Is there a physical CCl4 loss process we don't understand, or are there emission sources that go unreported or are not identified?
With zero CCl4 emissions reported between 2007-2012, atmospheric concentrations of the compound should have declined at an expected rate of 4 percent per year.
Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model.
Improvement of phase I drug metabolism with Schisandra chinensis against CCL4 hepatotoxicity in a rat model.
Biochemical mechanism of hepatic protective effect of geniposide on liver injured mice induced by CCL4.