cathepsin

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Related to Cathepsin S: Cathepsin L

cathepsin

 [kah-thep´sin]
an endopeptidase found in most cells, which takes part in cell autolysis and self-digestion of tissues.

ca·thep·sin

(kă-thep'sin),
One of a number of intracellular proteinases and peptidases (all endopeptidases) of animal tissues of varying specificities.

cathepsin

/ca·thep·sin/ (kah-thep´sin) one of a number of enzymes each of which catalyzes the hydrolytic cleavage of specific peptide bonds.

cathepsin

(kə-thĕp′sĭn)
n.
Any of various enzymes found in animal tissue that catalyze the hydrolysis of proteins into smaller proteins.

cathepsin

Any ENZYME that acts to split the interior PEPTIDE bonds of a protein, causing its decomposition.

cathepsin

or

kathepsin

the intracellular, proteolytic enzymes that bring about AUTOLYSIS.

cathepsin

a proteinase found in most cells, which takes part in cell autolysis and self-digestion of tissues.

cathepsin D
an acid hydrolase isolated from cartilage which plays a part in the endogenous degradation of proteoglycans in degenerative diseases of joints.
References in periodicals archive ?
Inhibition of cathepsin S is likely to result in a reduction in antigen presentation without an impact on innate immunity.
We are excited by the potential that this cathepsin S inhibitor program has for the treatment of autoimmune diseases and how it will complement our pipeline," said Darlene Jody, MD, Head of Specialized Therapeutics Global Business Unit at Schering Group.
In model systems, cathepsin S mediated microglial activation is essential in the development of pain.
The project aims to develop a pharmaceutical for autoimmune and allergic disorders; based on the inhibition of the protease enzyme Cathepsin S.
Celera Genomics has designed and synthesized extremely potent and selective compounds which demonstrate picomolar inhibitory potency against the cathepsin S enzyme and which also show inhibitory activity in cell systems in the nanomolar range.
Cathepsin S is an enzyme involved in the activation of immune system T-cells.
The most recent milestone payment recognizes selection of Celera Cathepsin S inhibitor compounds as Early Development Candidates (EDC) for inflammation and autoimmune diseases.
We look forward to continuing to work closely with J&JPRD to advance our research in discovering small molecule Cathepsin S inhibitors," stated Daniel Swisher, CEO of Sunesis Pharmaceuticals.
Cathepsin S is a protease (protein degrading enzyme) that plays a significant role in the activation of certain immune responses.
The Cathepsin S program is a joint-venture between Medivir and Peptimmune Inc.
Peptimmune and Medivir are jointly developing small molecule inhibitors of Cathepsin S.
Cathepsin S is a protease enzyme that plays a central role in the initiation of an immune response.