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cathepsin |
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cathepsin /ca·thep·sin/ (kah-thep´sin) one of a number of enzymes each of which catalyzes the hydrolytic cleavage of specific peptide bonds. cathepsin a proteinase found in most cells, which takes part in cell autolysis and self-digestion of tissues. cathepsin D an acid hydrolase isolated from cartilage which plays a part in the endogenous degradation of proteoglycans in degenerative diseases of joints. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Flatworms taken from mice treated with the drug showed reduced activity of the cysteine protease called cathepsin B, suggesting that this enzyme is a prime target of K11777. Neutrophils exhibit defective chemotaxis and reduced intracellular killing for up to 90 minutes after bacterial phagocytosis, and their granules lack the serine proteases cathepsin G and elastase because of a failure of normal protein sorting (68,69). Since papain is closely related to cathepsin B, a thiol endopeptidase which is released by cells of the inflammatory response, the authors concluded that segmented poly-etherurethanes can be degraded by enzymes which are present during the inflammatory response. |
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