catenin

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ca·ten·in

(ka-tēn'in),
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β-catenin, which is linked to the cadherin itself and α-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.

ca·ten·in

(kă-tē'nin)
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: beta-catenin, which is linked to the cadherin itself, and alpha-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

catenin

a PROTEIN initially characterized because of its association with the ACTIN of the CYTOSKELETON, where it acts as a bridging protein between CADHERIN and actin.
References in periodicals archive ?
Most BSSs showed preserved expression of E-cadherin (12 of 14; 86%) and its associated catenins ([beta], 7 of 14 [50%]; [alpha]- and [gamma]-catenins, 8 of 14 [57%]) in at least one of the histologic component.
In contrast to BSSs, significantly down-regulated expression of E-cadherin (1 of 27; 4%), and the catenins ([alpha], 1 of 27 [4%]; [beta], 3 of 27 [11%]; and [gamma], 1 of 27 [4%]) was observed in the MFSSs.
Catenins as mediators of the cytoplasmic functions of cadherins.
Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of [beta]-catenin mutations in synovial sarcoma.
These two catenins bind as a complex to cell surface adhesion molecules called cadherins.
A selection of these pre-clinical compounds and drug candidates from the new catenin inhibitor family are scheduled to be evaluated for their anti-cancer effects and vascular targeting capabilities as part of the recently announced agreement with the US National Cancer Institute.
4] After examination of the expression of cadherins and [Beta]-catenin, the distribution pattern of cadherin and catenin expression (plasma membrane, cytoplasm, or nucleus), intensity of staining, and percentage of cells stained were recorded.
The immunohistochemical staining was performed on a Biotek Techmate stainer and described previously,[4] except for the catenin studies, for which stains were performed manually.
Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation.
Prognostic value of the preserved expression of E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma.