catenin

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ca·ten·in

(ka-tēn'in),
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β-catenin, which is linked to the cadherin itself and α-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.

ca·ten·in

(kă-tē'nin)
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: beta-catenin, which is linked to the cadherin itself, and alpha-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

catenin

a PROTEIN initially characterized because of its association with the ACTIN of the CYTOSKELETON, where it acts as a bridging protein between CADHERIN and actin.
References in periodicals archive ?
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
52) A major role of catenins (including [alpha]-catenin, [beta]-catenin, plakoglobin, and p120 catenin) is to anchor the E-cadherin complex to the actin cytoskeleton.
Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ.
The p120 catenin is an intracellular protein that promotes the binding between the complex of catenins and cell cytoskeleton.
10] An alternative to reduce this interference and improve diagnosis is the combined use of immunohisto chemical markers of the catenin pathway.
At the end of metamorphosis (stage XX), catenins were found co-expressed with E-cadherin in all renal tubules, suggesting maturation of cadherin-catenin junction complexes.
Membrane cytoskeleton interactions with cadherin cell adhesion proteins: roles of catenins as linker proteins.
This patent, Adherex's 25th issued in the US, targets a distinct family of molecules inside cells called catenins and opens up the possibilities of a new realm of further therapeutic applications and a completely novel way to attack and destroy the blood vessels that feed a tumor.
The epithelial cells express E-cadherin and catenins ([alpha], [beta], and [gamma]), whereas the spindle cells react to vimentin focally and to N-cadherin.
4] After examination of the expression of cadherins and [Beta]-catenin, the distribution pattern of cadherin and catenin expression (plasma membrane, cytoplasm, or nucleus), intensity of staining, and percentage of cells stained were recorded.
Of these, the first two belong to the adherens junctions, where the adhesion molecules cadherin and catenin are present.