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catechol-o-methyl transferase |
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catechol-o-methyl transferase (COMT) [kat′əkol′ōmeth′il] an enzyme that deactivates the catecholamines dopa, dopamine, epinephrine, and norepinephrine. catechol-o-methyl transferase (COMT), n an enzyme that deactivates epinephrine and norepinephrine. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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DA is converted to DOPAC intraneuronally after re-uptake, whereas extraneuronal DA is converted to HVA by the enzymes catechol-O-methyltransferase and monoamine oxidase. This genetic alteration reduces the production of the enzyme catechol-O-methyltransferase, or COMT, which helps terminate the action of the neurotransmitters dopamine and norepinephrine, reports a research team headed by psychiatric geneticist Maria Karayiorgou of Rockefeller University in New York. Correlation of erythrocyte catechol-O-methyltransferase activity between siblings. |
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