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catechol-o-methyl transferase
(redirected from Catechol-o-methyltransferase)

   Also found in: Wikipedia 0.01 sec.
catechol-o-methyl transferase (COMT)
[kat′əkol′ōmeth′il]
an enzyme that deactivates the catecholamines dopa, dopamine, epinephrine, and norepinephrine.

catechol-o-methyl transferase (COMT),
n an enzyme that deactivates epinephrine and norepinephrine.


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The researchers then looked at the polymorphisms in genes that coded for two enzymes that regulate monoamine levels: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A).
Carriers of the methionine allele of the catechol-O-methyltransferase (COMT) gene polymorphism proved far more sensitive to this adverse drug effect than were people who possessed the valine allele, added Ms.
This genetic alteration reduces the production of the enzyme catechol-O-methyltransferase, or COMT, which helps terminate the action of the neurotransmitters dopamine and norepinephrine, reports a research team headed by psychiatric geneticist Maria Karayiorgou of Rockefeller University in New York.
 
 
 
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