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catechol-o-methyl transferase
(redirected from Catechol-o-methyltransferase)

   Also found in: Acronyms, Wikipedia 0.03 sec.
catechol-o-methyl transferase (COMT),
n an enzyme that deactivates epinephrine and norepinephrine.

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DA is converted to DOPAC intraneuronally after re-uptake, whereas extraneuronal DA is converted to HVA by the enzymes catechol-O-methyltransferase and monoamine oxidase.
This genetic alteration reduces the production of the enzyme catechol-O-methyltransferase, or COMT, which helps terminate the action of the neurotransmitters dopamine and norepinephrine, reports a research team headed by psychiatric geneticist Maria Karayiorgou of Rockefeller University in New York.
Correlation of erythrocyte catechol-O-methyltransferase activity between siblings.
 
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