Researchers are now discovering that the activity of an enzyme called catechol-O-methyltransferase
, which is encoded by the COMT gene, may explain why some people are more resilient to stress than others.
inhibitors (COMT inhibitors) These are prescribed for people in later stages of Parkinson's disease.
Nevertheless, competition from clinical mainstays will make it difficult for late entrants like Newron/Zambon/Meiji Seika Pharma's monoamine oxidase B inhibitor safinamide, Bial/Ono's catechol-O-methyltransferase
inhibitor opicapone, and Adamas' extended-release amantadine formulation Nurelin to garner a substantial share of the market unless significant clinical differentiation can be shown.
The study suggested that common genetic variation in the gene for catechol-O-methyltransferase
(COMT) might modify the cardiovascular benefit of aspirin and in some people it might confer slight harm.
Other drugs used to treat PD are dopamine agonists, anti-cholinergic, MAO-B inhibitors and Catechol-O-Methyltransferase
Dopamine is metabolized by catechol-O-methyltransferase
into methoxytyramine within head and neck paragangliomas (HNPGL).
(COMT) enzyme which is principally responsible for both the inactivation and detoxification of carcinogenic catechol estrogens.
The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase
(COMT)-mediated O-methylation of these dietary catechols.
Among HFD-fed mice, maternal TCDD exposure caused rapid mammary development with increased cytochrome P450 (Cyp 1b1) gene expression and decreased catechol-O-methyltransferase
Carriers of the methionine allele of the catechol-O-methyltransferase
(COMT) gene polymorphism proved far more sensitive to this adverse drug effect than were people who possessed the valine allele, added Ms.
This genetic alteration reduces the production of the enzyme catechol-O-methyltransferase
, or COMT, which helps terminate the action of the neurotransmitters dopamine and norepinephrine, reports a research team headed by psychiatric geneticist Maria Karayiorgou of Rockefeller University in New York.
The global PD therapeutics market is primarily served by levodopa, dopamine agonists, Monoamine Oxidase Inhibitors (MAO-BI) and Catechol-O-Methyltransferase