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active site
(redirected from Catalytic domain)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
active site
n.
The part of an enzyme molecule at which catalysis of the substrate occurs.

active site,
the place on the surface of an enzyme where its catalytic action occurs.

active
not passive.

active principle
the drugs or chemicals in a pharmaceutical preparation that exert an effect pharmacologically; as distinct from the inert fillers, wetting agents and other excipients also often included.
active site
that region of a protein, usually an enzyme, that binds to another molecule such as the substrate of the enzyme.
active transport
the movement of ions or molecules assisted by a carrier protein across the cell membranes and epithelial layers, usually against a concentration gradient, resulting directly from the expenditure of metabolic energy. For example, under normal circumstances more potassium ions are present within the cell and more sodium ions extracellularly. The process of maintaining these normal differences in electrolytic composition between the intracellular fluids is active transport. The process differs from simple diffusion or osmosis in that it requires the expenditure of metabolic energy.


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The FHA domain is linked to the kinase/phosphatase catalytic domain by a flexible tether, and it exhibits a mode of target selection based on electrostatic complementarity between the binding surface and the phosphothreonine peptide.
Schering Corporation (Kenilworth, NJ) has patented a modified tumor necrosis factor-alpha converting enzyme catalytic domain, that unlike the native tumor necrosis factor-alpha converting enzyme catalytic domain, is stable at high protein concentrations.
Cysteine Residues in the Catalytic Domain of Furin are Essential for Catalytic Activity and Proper Subcellular Trafficking.
 
 
 
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