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active site |
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active site, the place on the surface of an enzyme where its catalytic action occurs. active not passive. active principle the drugs or chemicals in a pharmaceutical preparation that exert an effect pharmacologically; as distinct from the inert fillers, wetting agents and other excipients also often included. active site that region of a protein, usually an enzyme, that binds to another molecule such as the substrate of the enzyme. active transport the movement of ions or molecules assisted by a carrier protein across the cell membranes and epithelial layers, usually against a concentration gradient, resulting directly from the expenditure of metabolic energy. For example, under normal circumstances more potassium ions are present within the cell and more sodium ions extracellularly. The process of maintaining these normal differences in electrolytic composition between the intracellular fluids is active transport. The process differs from simple diffusion or osmosis in that it requires the expenditure of metabolic energy. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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One of the most interesting ribozymes Bartel and his colleagues found had a catalytic domain 93 nucleotides long. In the majority of the cases they are designed to target a specific functional and catalytic domain of the protein. The study describes the crystal structure of VX-680 bound to the catalytic domain of BCR-ABL containing a mutation that causes Gleevec resistance but is inhibited by VX-680 in vitro. |
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