ribozyme

(redirected from Catalytic RNA)
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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.

ribozyme

enzyme whose catalytic function is carried out by an RNA subunit; of the four known classes, three carry out self processing reactions while the fourth, ribonuclease P (RNase P), is a true catalyst; discovered in the context of RNA splicing.
References in periodicals archive ?
Even with the Berkeley group's advances in making proteins with synthetic amino acids, deliberate engineering of catalytic RNA to perform specific molecular jobs may still emerge as an easier task, Benner asserts, Protein designers still do not understand how linear sequences of amino acids fold into the three-dimensional arrangements they must assume to function properly.
Innovir Laboratories is a biotechnology company currently in development of a new class of biopharmaceutical therapeutic agents based on catalytic RNA (ribozymes).
Innovir is a biotechnology company founded in 1989 to develop a new class of biopharmaceutical therapeutic agents based on catalytic RNA enzymes, or ribozymes.
Moreover, scientists trying to understand how life began now look to catalytic RNA molecules, or ribozymes, as likely biochemical ancestors that evolved into the DNA-RNA-protein progression of modern cells (SN: 6/17/89, p.
Innovir is a biotechnology company founded in 1989 to develop a new class of biopharmaceutical therapeutic agents based on catalytic RNA (ribozymes) for the treatment of a broad array of diseases including hepatitis B virus infection and acute promyelocytic leukemia (APL).
Our research into catalytic RNA as a therapeutic for hepatitis B and acute promyelocytic leukemia, as well as other diseases, has continued on schedule.
Hammerhead ribozymes are small catalytic RNAs that cleave single stranded RNA substrates at specific nucleotide sequences.
Ribozymes are small catalytic RNAs that specifically cleave single-stranded RNA targets.
Until now, research has indicated that catalytic RNAs perform only a "limited range of reactions" -- making and breaking bonds in RNA.

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