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Castleman's disease
(redirected from Castleman disease)

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
Castleman's disease
[kas′əlmənz]
Etymology: Benjamin Castleman, American pathologist, 1906-1982
a condition resembling lymphoma but without recognizable malignant cells, characterized by isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area. One variety has numerous small germinal centers near blood vessels with vascular proliferation; a second type consists of sheets of plasma cells and fewer but larger germinal centers. The disease may be either benign or premalignant and overlap with autoimmune diseases. Also called benign giant lymph node hyperplasia.

Castleman's disease
A heterogeneous group of idiopathic, multicentric lymphoproliferative disorders primarily of young adults Clinical Hepatosplenomegaly, lymphadenopathy Lab ↑ IL-6 in serum and tissues, anemia, hypoalbuminemia, hypergammaglobulinemia Management Surgical resection


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Human herpesvirus 8 (HHV-8) has been detected in patients with Kaposi sarcoma, primary-effusion B-cell lymphomas, and Castleman disease (1).
Kimura disease is sometimes confused with angiolymphoid hyperplasia with eosinophilia, Hodgkin lymphoma, angioimmunoblastic T-cell lymphoma, florid follicular hyperplasia, Castleman disease, and lymphadenopathy secondary to drug reactions and parasitic infections.
 
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