Castleman's disease


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Castleman's disease

[kas′əlmənz]
Etymology: Benjamin Castleman, American pathologist, 1906-1982
a condition resembling lymphoma but without recognizable malignant cells, characterized by isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area. One variety has numerous small germinal centers near blood vessels with vascular proliferation; a second type consists of sheets of plasma cells and fewer but larger germinal centers. The disease may be either benign or premalignant and overlap with autoimmune diseases. Also called benign giant lymph node hyperplasia.

Castleman's disease

A heterogeneous group of idiopathic, multicentric lymphoproliferative disorders primarily of young adults Clinical Hepatosplenomegaly, lymphadenopathy Lab ↑ IL-6 in serum and tissues, anemia, hypoalbuminemia, hypergammaglobulinemia Management Surgical resection
References in periodicals archive ?
Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease.
2014, Janssen under Johnson & Johnson announced the FDA had approved SYLVANT (siltuximab) for the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.
Castleman's disease (CD) is a non-clonal lymph node hyperplasia and was first described in 1956 by Benjamin Castleman and colleagues.
Other features of Castleman's disease included the 'onion skin' arrangement of the surrounding lymphocyte (Fig.
Today s approval of a treatment for patients with multicentric Castleman's disease marks a significant milestone for patients living with this rare disease and underscores the importance of ongoing research and development in areas where there are so few patients with such a high unmet medical need, said Peter L.
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder.
Generalized lymphadenopathy with morphologic features of Castleman's disease in an HIV-positive man.
Castleman's disease in the retropharyngeal space: CT and MR imaging findings.
Castleman's disease arising from the accesory spleen: ultrasonography, computed tomography, and magnetic resonance imaging findings.
THE Blues under-16s development team showed their class defeating a strong Pentyrch, side 35-10 in a charity match for Castleman's disease.