Aetiology is not well understood however association with Castleman's disease
and Epstein Barr virus has been reported.
Multicentric Castleman's disease
with abundant IgG4-positive cells: a clinical and pathological analysis of six cases.
(CD) is a rare lymphoproliferative syndrome typically involving a mediastinal mass.
Excisional biopsy was performed and the histopathology showed the lesion to be hyalinized vascular type of castleman's disease
is a rare benign lymphoproliferative disorder of unknown aetiology and pathogenesis that primarily affects lymph nodes.
commonly involves mediastinum and hence it is thoracic in most of the reported cases.
Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease
(CD) is a non-clonal lymph node hyperplasia and was first described in 1956 by Benjamin Castleman and colleagues.
Other features of Castleman's disease
included the 'onion skin' arrangement of the surrounding lymphocyte (Fig.
Today s approval of a treatment for patients with multicentric Castleman's disease
marks a significant milestone for patients living with this rare disease and underscores the importance of ongoing research and development in areas where there are so few patients with such a high unmet medical need, said Peter L.
is an uncommon benign lymphoproliferative disorder characterized by hypervascular lymphoid hyperplasia.
Therefore, Kaposi Sarcoma and Multicentric Castleman's Disease
should be considered in the differential diagnosis (8).