CASP1

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CASP1

A gene on chromosome 11q23 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development.

Molecular pathology
CASP1 mutations may play a role in Huntington’s disease.
References in periodicals archive ?
Caspase-1 also controls the secretion of IL-1E-, but the mechanism and route of secretion are unknown.
This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death.
Most published research suggested that caspase-11 was necessary only to activate caspase-1.
Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis.
This assembly, the researchers explained, activates a powerful, protein-cleaving enzyme called caspase-1.
Friedlander of Brigham and Women's Hospital in Boston and his colleagues worked with mice harboring a gene for an inhibitor of caspase-1.
The preclinical data demonstrate that DPP 8 and DPP 9 inhibition may cause the activation of caspase-1 which leads to an increase in a key cytokine, interleukin-1beta (IL-1beta).
The extracellular adenosine activates the enzyme caspase-1, which triggers production of the cytokine IL-1 beta, a critical player in inflammation, he said.
Company Licenses Caspase-1 From Johannes Gutenberg University, Mainz, Germany
The initiator caspases including caspase-1, -8, -9, typically caspase-8 and caspase-9, are activated by two alternative pathways (Salvesen and Dixit, 1997).

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