Casodex

Casodex,

a trademark for an anticancer chemotherapy agent (bicalutamide).

bicalutamide Warning - Hazardous drug!

Casodex

Pharmacologic class: Nonsteroidal antiandrogen

Therapeutic class: Antineoplastic

Pregnancy risk category X

Action

Antagonizes effects of androgen at cellular level by binding to androgen receptors on target tissues

Availability

Tablets: 50 mg

⊘Indications and dosages

➣ Metastatic prostate cancer

Adults: 50 mg P.O. once daily

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• previous hypersensitivity or serious adverse reaction to flutamide or nilutamide
• moderate to severe hepatic impairment
• children.

Administration

• Know that drug is given in combination with luteinizing hormone-releasing hormone (LHRH).
• Administer at same time each day.

Route	Onset	Peak	Duration
P.O.	Unknown	31 hr	Unknown

Adverse reactions

CNS: headache, weakness, dizziness, depression, hypertonia, paresthesia, lethargy

CV: chest pain, peripheral edema, vasodilation, hypertension, thromboembolic disease

EENT: pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia, dry mouth

GU: urinary tract infection

Musculoskeletal: bone and back pain

Respiratory: dyspnea, cough

Skin: rash, alopecia

Other: food distaste, weight gain, edema, pain, hot flashes, flulike symptoms

Interactions

Drug-drug. Warfarin: increased bicalutamide effects

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, cholesterol: increased levels

Hemoglobin, white blood cells: decreased values

Patient monitoring

• Monitor prostate-significant antigen levels, CBC, and liver and kidney function test results.
• If patient is receiving warfarin concurrently, evaluate prothrombin time and International Normalized Ratio.

Patient teaching

• Instruct patient to take drug at same time each day, along with prescribed LHRH analog.
• Tell patient that any drug-related hair loss should reverse once therapy ends.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Mentioned in	?		References in periodicals archive	?		Medical browser	?		Full browser	?
Antiandrogen Drugs bicalutamide	Among them are Merck's osteoporosis drug Fosamax, AstraZeneca's cancer treatment Casodex and Glaxo SmithKline's asthma medicines Advair and Serevent. Israel's Teva buys US copycat drug rival for $7.5bn by guardian.co.uk / guardian.co.uk A subcutaneous, three-month Zolodex injection was immediately administered, and, with a daily Casodex tablet, a double hormonal blockade was instituted. Recovered Gerson patient tells his story: my recovery from prostate ... by Khalaf, Issa / Gerson Healing Newsletter Results of the world's largest prostate cancer trial, involving nearly 9,000 men in 23 countries, showed that the addition of Casodex (bicalutamide) to standard treatment reduces by almost half the risk of the disease progressing. medical round-up by The Mirror (London, England)	caseation caseation necrosis casein Casein hydrolysate caseinogen caseopurulent caseous caseous abscess caseous fermentation caseous lymphadenitis caseous necrosis caseous osteitis caseous rhinitis caseworm CASH cash budget cash cycle cash flow cash out cashmere cashmere goat cashmere wool casings for sausage Caslick CaSO 4 Casodex Casoni's test caspofungin caspofungin acetate CASS Cassadan cassaine cassava cassette Cassia Cassia spp Cassine buchanani Cassou artificial insemination gun cassowary cast CAST 2 cast brace cast care: maintenance cast care: wet cast core cast saw cast shoe cast stabilization Castalis spectabilis castanospermine Castanospermum australe	CASMII CASMIM CASMIN Casmir effect Casmir effect CASMIRC CASMIS CASMO CASMP CASMS CASMU CASN CASNA CASNAV CASNET Casnewydd Casnewydd Casnicki Namjesnik CASNR CASNS Caso CaSO 4 CaSO 4 CaSO 4 Caso fortuito Caso y Andrade, Alfonso Caso, Alfonso CASOC Casodex CASODOM CASOM CASON Casona, Alejandro Casoni's test CASOP Casorati, Felice Casorati-Weierstrass Theorem CASOS CASP CASP2 CASP3 CASP8 and FADD-Like Apoptosis Regulator CASPA CASPAA Caspar Caspar Caspar Caspar Bartholin Caspar Bauhin Caspar Berthelsen Bartholin Caspar David Friedrich Caspar David Friedrich Instituts Caspar David-Friedrich Caspar de Crayer Caspar F. Wolff

Mentioned in

References in periodicals archive

Medical browser

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Antiandrogen Drugs
bicalutamide

Among them are Merck's osteoporosis drug Fosamax, AstraZeneca's cancer treatment Casodex and Glaxo SmithKline's asthma medicines Advair and Serevent.

Israel's Teva buys US copycat drug rival for $7.5bn by guardian.co.uk / guardian.co.uk

A subcutaneous, three-month Zolodex injection was immediately administered, and, with a daily Casodex tablet, a double hormonal blockade was instituted.

Recovered Gerson patient tells his story: my recovery from prostate ... by Khalaf, Issa / Gerson Healing Newsletter

Results of the world's largest prostate cancer trial, involving nearly 9,000 men in 23 countries, showed that the addition of Casodex (bicalutamide) to standard treatment reduces by almost half the risk of the disease progressing.

medical round-up by The Mirror (London, England)