CASK

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CASK

A gene on chromosome Xp11.4 that encodes a calcium/calmodulin-dependent serine protein kinase of the membrane-associated guanylate kinase (MAGUK) family, which are scaffold proteins located at synapses in the brain. CASK is involved in synaptic transmembrane protein anchoring and ion channel trafficking; contributes to neural development and regulating gene expression by interacting with the transcription factor TRB1; binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans; and may mediate a link between the extracellular matrix and the actin cytoskeleton with syndecan and the actin/spectrin-binding protein 4.1.
 
Molecular pathology
CASK mutations are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, as well as an X-linked form of mental retardation.
References in periodicals archive ?
The casks owners will then have the opportunity to bottle the spirit, complete with a limited-edition Lagg Cask society label, or pay an annual fee to continue the maturation process until the desired age is attained.
This recent sale exceeds the previous record of just under HK$2 million, also held by a cask of Macallan whisky sold at Spink auction house China, set on Friday 4 July 2014.
Glenmorangie's collaboration with Renovo is the second partnership in the Distillery's Beyond the Cask series, which celebrates the casks in which Glenmorangie Original is matured, by repurposing their staves in innovative ways.
The casks are checked on twice per shift by security and once per shift by the operations department to make sure they haven't been tampered with.
Market share of players/leading players for SNF dry storage casks market in 2015.
Dalmore Distillery has an extensive collection of casks, from 12-year-olds to 21 and beyond.
Steve said: "We are primarily a cask ale brewery, but as we grow our business Storr is winning new followers.
It is aged in bourbon casks and Iain explains: "We have flavour from two places; the spirit, and the character within it, then we put it in the cask and let the cask add to character.
The operation requires extreme caution, as any damage to the fuel rods or the casks would cause high-level radiation.
Herradura ages the tequila in American oak barrels for 11 months, then transfers it to French oak casks sourced from France's Cognac region for three more months.
The single malts were married in European oak casks to produce just 5,000 cases (or 60,000 bottles, each with 700ml of the whisky in it), which were released last year to commemorate the 80th anniversary of Sir Alexander Walker's creation, the 'swing' bottle, which was special because it didn't topple over even on choppy seas, making it the favourite of the travelling elite of his time.