CASK

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CASK

A gene on chromosome Xp11.4 that encodes a calcium/calmodulin-dependent serine protein kinase of the membrane-associated guanylate kinase (MAGUK) family, which are scaffold proteins located at synapses in the brain. CASK is involved in synaptic transmembrane protein anchoring and ion channel trafficking; contributes to neural development and regulating gene expression by interacting with the transcription factor TRB1; binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans; and may mediate a link between the extracellular matrix and the actin cytoskeleton with syndecan and the actin/spectrin-binding protein 4.1.
 
Molecular pathology
CASK mutations are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, as well as an X-linked form of mental retardation.
References in classic literature ?
And as the carter went on with the other two horses, she again crept under the tilt of the cart, and pecked out the bung of the second cask, so that all the wine ran out.
Oodles and oodles of it, my gentlemen, in cask and chest, in cask and chest, a fathom under the sand.
Oodles and oodles of it, gold and gold and better than gold, in cask and chest, in cask and chest, a fathom under the sand," the Ancient Mariner assured him in beneficent cackles.
Where could he get a cask large enough to contain the right proportion of water?
Those who had been greedy with the staves of the cask, had acquired a tigerish smear about the mouth; and one tall joker so besmirched, his head more out of a long squalid bag of a nightcap than in it, scrawled upon a wall with his finger dipped in muddy wine-lees--BLOOD.
The assessment of solar insulation impact to casks in the new storage facility is not necessary, because the casks are stored in a closed facility and direct solar radiation is not relevant.
Funding support from Wirral council and help from Barclays Bank and the Manufacturing Advisory Service (MAS) provided pounds 25,000 of capital which has been invested in 220 new ale casks and cask washing equipment to support its sales push.
The 11-strong workforce at Highgate Brewery in Sandy Mount Road, Walsall, can look forward to some Christmas cheer after being flooded with orders from all over the UK for their five-litre casks of traditional ale in time for the festive season.
A high proportion of malt whiskey matured in former Oloroso Sherry casks with a sweet, batch-distilled grain whiskey for rich fruity notes and deep intense character.
TWO casks of whiskey are set to make history this month when they become the first barrels transported to Dublin down the Grand Canal in half a century.
According to Dogfish founder and President Sam Calagione, "We decided to initially launch our 75 Minute casks in select accounts in key markets including New York, Philly and Boston, as well as our Rehoboth Beach brewpub.
The brew is aged on bourbon oak casks and whole Madagascar vanilla beans.