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COMET
(redirected from Carvedilol or Metoprolol European Trial)

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COMET
Cardiology Carvedilol or Metoprolol European Trial. A trial comparing carvedilol and immediate release metoprolol tartrate on clinical outcome in patients with moderate to severe heart failure
Conclusion Cardiovascular deaths occurred in 29% of carvedilol patients and in 35% of metoprolol patients
ENT Combined microscopic & endoscopic technique. An alternative to the technically demanding endoscopic sinus surgery for chronic sinus diseases, a technique which allows less experienced operators to manage these diseases with fewer complications


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The Carvedilol Or Metoprolol European Trial (COMET) compared carvedilol (target dose: 25 mg bid) to metoprolol tartrate (target dose: 50 mg bid).
Poole-Wilson PA, Swedberg K, Cleland JGF, et al, Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET); a randomized control trial.
Although the efficacy of bisoprolol, carvedilol, and metoprolol has been documented in studies that compared each of these drugs against placebo, two of these agents were compared with each other in just one reported study, the Carvedilol or Metoprolol European Trial (COMET) (Lancet 2003;362:7-13).
 
 
 
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