Purpose: The current study aimed to investigate the possible protective effect of Rg3 against ADM-induced cardiotoxicity
Despite the benefits of anthracyclines, cardiotoxicity
remains the main limitation of anthracycline-based chemotherapy.
She collapsed and died 31 years ago; the cause of death was emetine cardiotoxicity
- a consequence of anorexia nervosa.
Among specific topics are atrial fibrillation and cardiomyopathy with heart failure, cardiac resynchronization therapy, evaluating and managing the heart transplant candidates, the cardiotoxicity
of anti-cancer treatment, and the role of risk modeling in heart failure.
However, its use is limited by its cardiotoxicity
, which can lead to heart failure.
Objective: To investigate cardioprotective effect of WFEP against doxorubicin (Dox)-induced cardiotoxicity
In an effort to improve preclinical cardiotoxicity
assays, reduce drug testing attrition rates, and ensure drug safety, collaborating scientists at the University Medical Center Utrecht in the Netherlands, and Bioscience Department of AstraZeneca R&D, Molndal, Sweden, have tested Roche's xCELLigence Cardio Instrument.
After adjustment for these traditional cardiovascular risk factors as well as for other factors that predispose to heart failure, including prior treatment with anthracyclines or radiation therapy, the group taking beta-blockers had an adjusted 83% lower risk of developing cardiotoxicity
during 1 year of follow-up on trastuzumab (P =.
Possible major cardiotoxicity
which has been reported include cardiomyopathy, coronary artery disease and atherosclerosis [2,3].
In patients using anthracycline group of medicines, cardiotoxicity
which develops both in short-term (during the first year of treatment) and in long-term follow up up to 20 years after treatment (chronic period) is well known.
According to the researchers, cardiotoxicity
affects as many as 34% of patients treated with trastuzumab for breast cancer.
is a rare side effect of this compound (1).