Carney's complex

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Carney's complex

Cardiology A variable clinical complex of mucocutaneous, visceral, and endocrine disorders, defined by ≥ 2 of the following
Carney's complex
Cardiac myxoma
Cutaneous myxoma
Mammary myxoid fibroma
Spotty mucocutaneous pigmentation
Lentigines, blue, junctional or compound nevi
Primary pigmented nodular adrenocortical disease
testicular tumor
large cell calcifying Sertoli cell tumors, often bilateral/multicentric
Pituitary hGH-secreting tumor
–Acromegaly or gigantism (MCP 1986; 61:165)
References in periodicals archive ?
PINEDE L, DUHAUT P, LOIRE R--Clinical presentation of left atrial cardiac myxoma.
A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome.
Symptoms from a cardiac myxoma are more pronounced when the myxomas are left-sided, racemosus, and over 5 cm in diameter [6].
We reported a large left atrial cardiac myxoma and paradoxical pulmonary emboli to the upper lobe of the left lung from a patent large foramen ovale subsequently.
Treatment of cardiac myxoma is by surgical resection via median sternotomy and is generally curative.
The diagnosis of Carney complex requires 2 manifestations of the following: typical mucocutaneous pigmentation, cardiac myxoma, breast myxomatosis or adenoma, endocrine overactivity, testicular tumors, schwannoma, and pituitary adenoma.
Central Nervous System Manifestations of Cardiac Myxoma.
Cardiology evaluation including echocardiogram was done to rule out cardiac myxoma.
The data also shows that cardiac myxoma occur predominantly in females who comprise approximately two thirds of all studied myxoma cases (6).
In one of them ischemic stroke was secondary to arrhythmic ischemic heart disease, in 5 it was related with various cardiac failures, such as, congenital heart disease (n=1), cardiac myxoma (n=1), cyanotic CHD with atrial fibrillation like heart rhythm disorder (n=3).
Vascular endothelial growth factor is an autocrine growth factor for cardiac myxoma cells.