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cardiac action potential |
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cardiac action potential, the transmembrane potential in the heart, consisting of five phases: 0, the upstroke or rapid depolarization, which initiates the heartbeat in response to an influx of Na+; 1, early rapid repolarization; 2, plateau in response to an influx of Ca2+; 3, final rapid repolarization in response to an influx of K+; and 4, resting membrane potential and diastolic depolarization. Abnormalities of the heart or its conduction system that alter the cardiac action potential lead to the development of cardiac arrhythmias. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The effects of potassium channel gene regulation on ion currents, protein density, and the cardiac action potential have been demonstrated previously. Cardiac output can be influenced by drugs that directly affect the heart by altering either myocardial contractility or the initiation and conduction of the cardiac action potential. |
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