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cardiac action potential

   Also found in: Wikipedia 0.01 sec.
cardiac action potential,
the transmembrane potential in the heart, consisting of five phases: 0, the upstroke or rapid depolarization, which initiates the heartbeat in response to an influx of Na+; 1, early rapid repolarization; 2, plateau in response to an influx of Ca2+; 3, final rapid repolarization in response to an influx of K+; and 4, resting membrane potential and diastolic depolarization. Abnormalities of the heart or its conduction system that alter the cardiac action potential lead to the development of cardiac arrhythmias.


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Thus, the most important toxic effect of TCAs is the slowing of depolarization of the cardiac action potential by inhibition of the sodium current and this delays propagation of depolarization through both myocardium and conducting tissue.
] current important for the repolarization phase of the cardiac action potential.
The effects of potassium channel gene regulation on ion currents, protein density, and the cardiac action potential have been demonstrated previously.
 
 
 
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