pneumoniae were the main pathogens;[sup], drug sensitivity tests showed that there were varying degrees of resistance to carbapenem antibiotics
Inhibition mechanism of carbapenem antibiotics
on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid.
are widely used in hospitals to treat severe infections.
The carbapenem antibiotic
disks used for each isolate were ertapenem (10mg), imipenem (10mg), meropenem (10mg) and doripenem (10mg).
According to the report, resistance to the treatment of last resort for life- threatening infections caused by a common intestinal bacteria, Klebsiella pneumonia -- carbapenem antibiotics
-- has spread to the entire world.
Key findings from the report included that resistance to the treatment of last resort for life-threatening infections caused by a common intestinal bacteria, Klebsiella pneumoniae carbapenem antibiotics
has spread to all regions of the world.
Prof Neil Woodford, of Public Health England, said: "KPC is one of a number of enzymes that can make a bacteria resistant to carbapenem antibiotics
In some parts of the world, only the carbapenem antibiotics
class remains effective, but now signs are emerging of resistance even to this last line of defence.
should be treated as the last resort and reserved for severe infections.
In-vitro activity of carbapenem antibiotics
against beta-lactam susceptible and resistant strains of Burkholderia pseudomallei.
Resistance to carbapenem antibiotics
was detected at very low level in poultry and in chicken meat in two Member States (fifteen E.