TRPV1

(redirected from Capsaicin receptor)

TRPV1

A gene on chromosome 17p13.2 that encodes a protein which is a receptor for capsaicin and the structurally related vanilloids, and is a non-selective cation channel structurally related to the TRP family of ion channels. The receptor is also activated by high temperatures, suggesting that it functions as a transducer of noxious chemical and painful thermal stimuli in vivo.
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There is a receptor on the nerves called TRPV1 (transient receptor potential cation channel, subfamily V [vanilloid], member 1), whose previous name was the capsaicin receptor.
In fact, TRPV1 is often called the capsaicin receptor.
Other recent studies have shown that some itch inducers -- called pruritogens -- lead to activation of the capsaicin receptor, a pain receptor named for the incendiary chemical in chili peppers.
Impaired nociception and pain in mice lacking the capsaicin receptor.
The cloned capsaicin receptor integrates multiple pain-producing stimuli.
University of California (Oakland, CA) has patented vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2, as well as the encoding polynucleotide sequences.
The capsaicin receptor, vanilloid receptor 1 (VR1), has been identified (Caterina et al.
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
After years of looking, researchers recently reported that they had finally identified the capsaicin receptor.
His group has cloned a number of neurotransmitter receptors and ion channels, including the capsaicin receptor, an integrator of multiple pain-producing stimuli.
Other recent studies have shown that some itch inducers, called pruritogens, lead to activation of the capsaicin receptor, a pain receptor named for the incendiary chemical in chili peppers.
Once it is in the stomach and intestines, it may not be sensed by some people because the nociceptive neurons serving those organs do not possess the capsaicin receptors.