Capillary Leak Syndrome

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A condition in which the size of the pores in the capillaries are increased, leading to a leakage of 10+ litres of fluid into the interstitial space, resulting in haemoconcentration, hypoalbuminaemia, severe hypotension, generalised oedema and multiple organ failure— cardiopulmonary collapse, and acute renal failure—due to acute tubular necrosis following hypovolemia, rhabdomyolysis, due to reduced perfusion, causing progressive dyspnea and pericarditis, high fever, confusion, and disorientation
Aetiology Cytokine therapy with IL-2, GM-CSF, used to treat metastatic cancer
Prognosis The high mortality in early reports has been reduced by prophylactic therapy using terbutaline, theophyllin
References in periodicals archive ?
Systemic capillary leak syndrome and monoclonal IgG gammapathy: studies in a sixth patient and review of the literature.
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome.
Systemic capillary leak syndrome associated with rhabdomyolysis and compartment syndrome.
Production of 5-lipoxygenase pathway metabolites by peripherical leucocytes in capillary leak syndrome (Clarkson disease).
Marrow engraftment and clinical manifestations of capillary leak syndrome.