At least two are in phase III, placebo-controlled trials: Axokine, or ciliary neurotrophic factor (Regeneron Pharmaceuticals), and Rimonabant, a cannabinoid receptor
When the researchers inserted this genetic code into cells grown in the lab, the cells bound marijuana-like substances, though not to the same degree as the brain's cannabinoid receptor
, Munro and his colleagues report in the Sept.
8,778,950, entitled "Cannabinoid Receptor
Modulators," by the United States Patent and Trademark Office for APD371, an agonist of the cannabinoid receptor
The mechanism may involve cannabinoid receptor
blockage in adipocytes in skeletal muscle and/or liver, Dr.
A CB1-selective cannabinoid receptor
antagonist known as SR14176 blocked the effects of smoking marijuana in volunteers with a history of marijuana use, said Marilyn A.
Cesamet is a synthetic cannabinoid that is thought to act as an omnineuromodulator - interacting with the cannabinoid receptor
, CB1, which is present throughout the nervous system.
Washington, January 5 ( ANI ): In a new study, researchers have just discovered the key role played by a protein, the CB1 cannabinoid receptor
, during physical exercise.
Rimonabant (Acomplia), an antagonist of the cannabinoid receptor
CB1, showed "very good results" for weight and waist circumference reductions at a study presented at an American College of Cardiology meeting in March 2004.
Prince said it's too early to know exactly how marijuana binding to the cannabinoid receptor
exerts its behavioral effects.
Although the research suggests a neuro-protective effect of cannabinoid receptor
activation in brain trauma induced inflammatory models, we are far from extrapolating that medical marijuana is a safe and effective method of treating humans with post-concussion syndrome.
Bradley Winters, lead author of the research paper and a freshly minted WSU doctor of neuroscience, said he, his major advisor Yan Dong, and colleagues at WSU, the University of Pittsburgh and the European Neuroscience Institute focused on cells that produce a signaling molecule called cannabinoid receptor
1, or CB1.
The researchers found that a synthetic cannabinoid agonist provokes relapse to cocaine craving, while a cannabinoid receptor
antagonist takes the edge off cravings induced by cocaine or cocaine cues, but not by stress (Nat.