Canarypox Virus

An avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds, which can enter but not survive and multiply in human cells; it was proposed as a live vector for HIV vaccines, as it can carry a large quantity of foreign genes
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However, 4 samples (18%) had antibody to canarypox virus antigen with test sample and negative control ratios (P/N values) ranging from 2.
Live canarypox virus that expresses the rabies virus glycoprotein has been licensed in the USA as a parenteral monovalent vaccine for cats and as a combination rabies vaccines for cats with feline panleukopenia virus, feline parvovirus, feline calicivirus vaccines included in the product (51).
Both strains were found in all 3 passerine taxa, and sequences from both strains were less than 5% different from each other and from canarypox virus.
Two vaccines are available for vaccinating equines: an inactivated WNV vaccine and a recombinant vaccine that uses canarypox virus to express WNV antigens (44,45).
The book finishes with presentations on a novel principle of attenuation for developing new generation live flavivirus vaccines, on tick-borne encephalitis, and on a recombinant vaccine developed from a canarypox virus carrying the prM/E genes of West Nile virus that will protect horses against a West Nile virus--mosquito challenge, and on diagnosis of zoonotic viral encephalitis.